“…White pepper Piper nigrum L. and long pepper Piper longum L. that from the family Piperaceae, are common used as spices all over the world. They have been used for the treatment of vomiting, diarrhea and digestion in traditional Chinese medicine 14 . Piperine, a main component of Piper species, is alkaloid with a long history of medical use in a variety of inflammatory disorders like rheumatoid arthritis 15 .…”