Responsible research and innovation (RRI) is a framework for thinking about the implications of science, technology, engineering, and math (STEM) discoveries and innovations and shaping them in a way that is responsible to people, future generations, and the natural environment. In this paper, we present a project that engages museum visitors in learning about RRI through hands-on activities inspired by Mary Shelley's Frankenstein story, characters, and themes. We developed a learning framework describing strategies and outcomes for RRI in informal educational settings, then created a set of seven activities that embodied the framework and studied their implementation at 13 museums. Evidence from observations and interviews are consistent with the RRI learning framework and suggest a number of practical implications for its use in museums.The struggles of Victor Frankenstein and his creature still resonate 200 years after the publication of Mary Shelley's novel Frankenstein; or, The Modern Prometheus (Shelley, 2018). The characters and key themes of the Frankenstein story are familiar, especially the fatal consequences of prioritizing personal ambition and scientific discovery over responsibility and ethics (Halpern et al., 2016;Hitchcock, 2007;Lederer, 2002). The emerging technologies of today-from artificial intelligence to genetic engineering-raise the same questions and dilemmas that came to Shelley's mind as she