STK11/LKB1 Mutation-positive Primary Thymic Mucinous Adenocarcinoma Accompanied by Cerebellar Metastasis: A Case Report and Literature Review

Primary mucinous adenocarcinoma of the anterior mediastinum with HER-2 mutation: A rare case report

“…In this study, we assess the feasibility of an innovative approach based on molecular testing. Reviewing genetic test results from previous studies on MAs, we found only two instances that indicated the presence of a KRAS mutation and STK11 deletion [ [6] , [8] , [9] ]. We conducted genetic testing on the patient's tissue samples twice, once from the mediastinal mass and once from the supraclavicular metastatic lymph nodes and both results were confirming the presence of the HER2 p.R678Q mutation.To our knowledge, this is the first reported case of HER-2 mutation in mediastinal MAs.…”

“…While it is crucial for diagnosis and treatment, determining the primary lesion remains a significant challenge. In this study, we have reviewed previous cases, including the results of immunohistochemistry, treatment modalities, and prognosis [ [5] , [6] , [7] , [8] , [9] , [10] , [12] ] ( Table 1 ). Immunohistochemical analysis of the cases reported previously exhibited similar characteristics to our case.…”