STK39 enhances the progression of Cholangiocarcinoma via PI3K/AKT pathway

Abstract

Highlights STK39 was overexpressed in CCA, negatively associated with the prognosis of patients with CCA STK39 knockdown suppressed cell proliferation and invasion. STK39 overexpression facilitated tumor aggressiveness STK39 mediates oncogenic effects on CCA cells by activating the PI3K/AKT signaling pathway STK39 reduces CCA sensitivity to gemcitabine. Increased expression of STK39 may be mediated by dysregulation of miR-26a-5p

The Ubiquitin-Proteasome System Participates in Sperm Surface Subproteome Remodeling during Boar Sperm Capacitation

“…Similar to the previous two examined proteins, the function of STK39 is well-known in somatic cells, where this cytosolic kinase, in synergy with oxidative stress-responsive kinase 1 (OXSR1, also known as OSR1), is essential for the regulation of Na + -K + -2Cl - cotransporters (NKCCs) [ 107 , 108 ] via the WNK-SPAK/OSR1 pathway [ 109 ], and thus, sustaining ion and fluid homeostasis in mammalian cells. The STK39 is expressed at high levels in normal human testes and the prostate [ 72 ], as well as in several cancer cell lines [ 72 , 73 , 110 , 111 , 112 , 113 ]. The importance of STK39 in mouse spermatogenesis was demonstrated by Liu et al [ 71 ], where a Sertoli cell-specific OSR1 −/− and STK39 −/− double-knockout male mice displayed infertility with increased germ cell apoptosis and defective spermatogenesis, resulting in Sertoli cell-only syndrome.…”