STM investigation of platinum oligomer clusters prepared by radiolysis

Keita, Bineta; Nadjo, Louis; Cointet, C. de; Amblard, J.; Belloni, J.

doi:10.1016/0009-2614(95)01425-x

Cited by 24 publications

(13 citation statements)

References 16 publications

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“…Despite the absence of adsorbed Pt ions, the stabilization by PA prevents aggregation and STM imaging shows 3È7 Pt atom oligomers. 34 In the presence of PP, the irradiated solution presents a UV band with a maximum at 215 nm.35 About 20% of the initial signal is lost by oxidation when the sample is exposed to air, the rest being stable. This result again conÐrms that the redox potential of the smallest clusters is markedly shifted to negative values.…”

Section: Monometallic Clustersmentioning

confidence: 99%

Radiation-induced synthesis of mono- and multi-metallic clusters and nanocolloids

Belloni¹,

Mostafavi²,

Remita³

et al. 1998

New J. Chem.

534

468

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Section: Monometallic Clustersmentioning

confidence: 99%

Radiation-induced synthesis of mono- and multi-metallic clusters and nanocolloids

Belloni¹,

Mostafavi²,

Remita³

et al. 1998

New J. Chem.

534

468

View full text Add to dashboard Cite

“…35 Different types of NPs have been synthesized following this methodology (Table 1). [36][37][38][39][40][41][42][43][44] However, in most of the cases, potentially toxic chemicals are used to control NPs formation and the final products are not adapted to straightforward medical use. Therefore, the development of efficient protocols able to produce non-toxic metallic nanoagents remains a challenge.…”

Section: Introductionmentioning

confidence: 99%

<p>Green One-Step Synthesis of Medical Nanoagents for Advanced Radiation Therapy</p>

Salado-Leza¹,

Porcel²,

Yang³

et al. 2020

NSA

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Purpose: Metal-based nanoparticles (M-NPs) have attracted great attention in nanomedicine due to their capacity to amplify and improve the tumor targeting of medical beams. However, their simple, efficient, high-yield and reproducible production remains a challenge. Currently, M-NPs are mainly synthesized by chemical methods or radiolysis using toxic reactants. The waste of time, loss of material and potential environmental hazards are major limitations. Materials and Methods: This work proposes a simple, fast and green strategy to synthesize small, non-toxic and stable NPs in water with a 100% production rate. Ionizing radiation is used to simultaneously synthesize and sterilize the containing NPs solutions. The synthesis of platinum nanoparticles (Pt NPs) coated with biocompatible poly(ethylene glycol) ligands (PEG) is presented as proof of concept. The physicochemical properties of NPs were studied by complementary specialized techniques. Their toxicity and radio-enhancing properties were evaluated in a cancerous in vitro model. Using plasmid nanoprobes, we investigated the elementary mechanisms underpinning radio-enhancement. Results and Discussion: Pt NPs showed nearly spherical-like shapes and an average hydrodynamic diameter of 9 nm. NPs are zero-valent platinum successfully coated with PEG. They were found non-toxic and have the singular property of amplifying cell killing induced by γ-rays (14%) and even more, the effects of carbon ions (44%) used in particle therapy. They induce nanosized-molecular damage, which is a major finding to potentially implement this protocol in treatment planning simulations. Conclusion: This new eco-friendly, fast and simple proposed method opens a new era of engineering water-soluble biocompatible NPs and boosts the development of NP-aided radiation therapies.

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“…Thus, dodecyl sulfate, polyphosphates, and polyacrylates serve to minimize interaction among clusters and enhance their lifetime 3 by providing a steric barrier to coalescence. More recently, the use of poly(acrylic acid) during the γ-radiolysis of solutions of Pt ions has led to the deposition on crystals of highly oriented pyrolytic graphite (HOPG) and scanning tunneling microscope (STM) imaging of well-resolved aggregates containing dimers, trimers, and tetramers of Pt, wherein the presence of adsorbed single atoms could not be ruled out …”

mentioning

confidence: 99%

Atomic Absorption by Free Atoms in Solution Following Chemical Reduction from the Ionic State

Panichev

Sturgeon

1998

Anal. Chem.

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The initial stages of chemical reduction of metallic ions in solution must proceed through the formation of single atoms, followed by the rapid formation of clusters with other atoms until continued coalescence produces observable precipitates or evidence of stable sol formation. Dilute solutions of sodium borohydride (0.0025%) merged with microgram per milliliter concentration solutions of Ag, Pd, and Cu in a custom spectrophotometric flow cell produce transient background-corrected atomic absorption signals during the initial few seconds of the reaction. High-resolution atomic absorption with both a hollow cathode line source and a continuum source reveals that the absorption line profile of the absorbing species is extremely narrow (11 pm for Ag) and not influenced by the aqueous environment. Such selective absorption of radiation suggests that free atoms are being observed in aqueous solution.

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STM investigation of platinum oligomer clusters prepared by radiolysis

Cited by 24 publications

References 16 publications

Radiation-induced synthesis of mono- and multi-metallic clusters and nanocolloids

Radiation-induced synthesis of mono- and multi-metallic clusters and nanocolloids

<p>Green One-Step Synthesis of Medical Nanoagents for Advanced Radiation Therapy</p>

Atomic Absorption by Free Atoms in Solution Following Chemical Reduction from the Ionic State

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