2024
DOI: 10.1101/2024.07.04.602131
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Stochastic Modeling of Biophysical Responses to Perturbation

Tara Chari,
Gennady Gorin,
Lior Pachter

Abstract: Recent advances in high-throughput, multi-condition experiments allow for genome-wide investigation of how perturbations affect transcription and translation in the cell across multiple biological entities or modalities, from chromatin and mRNA information to protein production and spatial morphology. This presents an unprecedented opportunity to unravel how the processes of DNA and RNA regulation direct cell fate determination and disease response. Most methods designed for analyzing large-scale perturbation … Show more

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