Stochastic Modelling of Insulin Sensitivity for out of Hospital Cardiac Arrest Patients Treated with Hypothermia

Abstract

Hypothermia is often used to treat out of hospital cardiac arrest (OHCA) patients who often simultaneously receive insulin for stress induced hyperglycaemia. Variations in response to insulin reflect dynamic changes in insulin sensitivity (S I ), defined by the overall metabolic response to stress and therapy. Thus, tracking and forecasting this parameter is important to provide safe glycaemic control in highly dynamic patients. This study examines stochastic forecasting models of model-based S I variability in OHCA patients to assess the resulting potential impact of this therapy on glycaemic control quality and safety.