In order to cope with the challenges of improving energy efficiency, increasing the integration of renewable energy, and achieving carbon emission reduction, multi‐energy systems have received more and more attention in recent years and have been developing rapidly. Traditionally, different energy infrastructures are usually scheduled and operated independently, which leads to inefficient use of energy and waste of resources. By integrating into a multi‐energy system, different energy infrastructures can be coupled and optimized into one unit. In this article, from a low‐carbon point of view, the optimal scheduling of a real multi‐energy system with hydrogen‐based vehicle applications is proposed. The simulation results show that the proposed optimal scheduling can help quantify the daily operation cost and carbon emissions and achieve considerably operating cost saving and carbon reduction by reasonably arranging and utilizing all the devices in the system.