On the basis of the quantitative prediction model for the waterÀoil relative permeability curve established in part 1 (10.1021/ef2008002), the conventional reservoir numerical simulator is modified and a new reservoir numerical simulation program is obtained, which can consider two simulation conditions. One is using different relative permeability curves in different simulation grids, it is called gridding of the relative permeability curve (GRPC) for short. The other is using a constant relative permeability curve in different simulation grids, it is called nongridding of the relative permeability curve (NGRPC) for short. On the basis of establishing the typical reservoir geological models, the reservoir numerical simulations under GRPC and NGRPC are carried out and the results are compared to each other. It is indicated that letting the relative permeability curve vary stochastically throughout the reservoir has little effect on flow characteristic and development performance of the whole reservoir, while it greatly affects the saturation of different permeability positions. Specifically, low-permeability grid cells are beneficial to the flow of the oil phase; therefore, the oil saturation will decrease. High-permeability grid cells are beneficial to the flow of the water phase; therefore, the oil saturation will increase. When the injection well is located in the low-permeability position and the production well is located in the high-permeability position, the distribution width of reservoir oil saturation under GRPC will become larger than that under NGRPC. In other words, reservoir oil saturation distribution will tend to be more dispersed. Meanwhile, the distribution frequency of the high oil saturation value will increase under GRPC, which indicates that the local enrichment of the remaining oil is easier to occur.