Stochastic Simulation for Biochemical Reaction Networks in Infectious Disease

Singh, Shailza; Shinde, Sonali

doi:10.5772/38245

Cited by 1 publication

(1 citation statement)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Any change in the biochemical network results in a change in the intercellular lipid trafficking and change in the membrane composition. As lipids play an important role in the virulence and multiplication of the parasite, any approach to disrupt the lipid metabolism could result in a therapeutic strategy to stop parasite proliferation and growth [5] . In this regard, a database LmSmdB was created which studies the network of interactions, maps pathways across taxonomic branches and also incorporates data obtained from simulation studies.…”

Section: Introductionmentioning

confidence: 99%

LmSmdB: an integrated database for metabolic and gene regulatory network in Leishmania major and Schistosoma mansoni

2016

Self Cite

View full text Add to dashboard Cite

A database that integrates all the information required for biological processing is essential to be stored in one platform. We have attempted to create one such integrated database that can be a one stop shop for the essential features required to fetch valuable result. LmSmdB (L. major and S. mansoni database) is an integrated database that accounts for the biological networks and regulatory pathways computationally determined by integrating the knowledge of the genome sequences of the mentioned organisms. It is the first database of its kind that has together with the network designing showed the simulation pattern of the product. This database intends to create a comprehensive canopy for the regulation of lipid metabolism reaction in the parasite by integrating the transcription factors, regulatory genes and the protein products controlled by the transcription factors and hence operating the metabolism at genetic level.

show abstract

Section: Introductionmentioning

confidence: 99%