The study examines the impact of interest rate on the stock market in the context of listed companies in NEPSE index. Stock price and stock return are selected as the dependent variables. The selected independent variables are bank rate, deposit interest rate, lending interest rate, base rate, inflation rate and capital adequacy ratio. The study is based on secondary data of 25 listed companies in NEPSE index with 200 observations for the period from 2013/14 to 2020/21. The data were collected from Banking and Financial Statistics published by Nepal Rastra Bank, publications and websites of Nepal Rastra Bank (NRB) and Ministry of Finance and annual reports of the selected listed companies. The correlation coefficients and regression models are estimated to test the significance and impact of interest rate on stock market in the context of listed companies in NEPSE index.The study showed that bank rate has a positive impact on stock price and stock return. It means that increase in bank rate leads to increase in stock price and stock return. Likewise, deposit interest rate has a negative impact on stock price and stock return. It means that increase in deposit interest rate leads to decrease in stock price and stock return. Similarly, lending interest rate has a negative impact on stock price and stock return. It shows that higher the lending interest rate, lower would be the stock price and stock return. Additionally, base rate has a negative impact on stock price and stock return. It indicates that increase in base rate leads to decrease in stock price and stock return. However, inflation rate has a positive impact on stock price and stock return. It indicates that increase in inflation rate leads to increase in stock price and stock return. Further, the study also showed that capital adequacy ratio has a negative impact on stock price and stock return. It means that higher the capital adequacy ratio, lower would be the stock price and stock return.