Stoffmonographie Pentachlorphenol-Referenz- und Human-Biomonitoring-Werte (HBM)

Umweltbundesamtes, Kommission «Human-Biomonitoring» des

doi:10.1007/bf03042913

Cited by 21 publications

(1 citation statement)

References 46 publications

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“…In contrast, in regard to carcinogens for which a threshold can be assumed, HBM-I and -II values comparable to those of non-carcinogens can be derived (e.g., for pentachlorophenol and cadmium, see [ 46 , 47 ]). If due to the lack of data neither a risk-based approach nor the derivation of HBM values is possible, reference values can be used at least to put the level of exposure in an orienting context.…”

Section: The Concept Of the Hbm Commission For The Assessment Of Carc...mentioning

confidence: 99%

Concept for the Evaluation of Carcinogenic Substances in Population-Based Human Biomonitoring

Wollin¹,

Apel

Chovolou

et al. 2022

IJERPH

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The Human Biomonitoring (HBM) Commission at the German Environment Agency holds the opinion that for environmental carcinogens for which no exposure levels can be assumed and are harmless to health, health-based guidance values corresponding to the classical definition of the HBM-I or HBM-II value cannot be established. Therefore, only reference values have been derived so far for genotoxic carcinogens from exposure data of the general population or subpopulations. The concept presented here opens up the possibility of performing health risk assessments of carcinogenic substances in human biomonitoring, and thus goes decisively beyond the purely descriptive statistical reference value concept. Using the presented method, quantitative dose descriptors of internal exposure can be derived from those of external exposure, provided that sufficient toxicokinetic information is available. Dose descriptors of internal exposure then allow the simple estimate of additional lifetime cancer risks for measured biomarker concentrations or, conversely, of equivalent concentrations for selected risks, such as those considered as tolerable for the general population. HBM data of chronic exposures to genotoxic carcinogens can thus be used to assess the additional lifetime cancer risk referring to the general population and to justify and prioritize risk management measures.

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Section: The Concept Of the Hbm Commission For The Assessment Of Carc...mentioning

confidence: 99%

Concept for the Evaluation of Carcinogenic Substances in Population-Based Human Biomonitoring

Wollin¹,

Apel

Chovolou

et al. 2022

IJERPH

View full text Add to dashboard Cite

show abstract

Pentachlorphenol [Biomonitoring Methods in German language, 1999]

Hoppe¹

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Analytische Methoden zur Prüfung gesundheitsschädlicher Arbeitsstoffe: Analysen in biologischem Material , 13. Lieferung, Ausgabe 1999 Der Artikel enthält folgende Kapitel: Grundlage des Verfahrens Geräte, Chemikalien und Lösungen Geräte Chemikalien Lösungen Vergleichsstandards Probenahme und Probenaufbereitung Instrumentelle Arbeitsbedingungen Analytische Bestimmung Kalibrierung Berechnung des Analysenergebnisses Standardisierung der Meßergebnisse und Qualitätssicherung Beurteilung des Verfahrens Präzision Richtigkeit Nachweisgrenze Störeinflüsse Diskussion der Methode

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Pentachlorphenol [Biomonitoring Methods in German language, 2000]

Heinrich‐Ramm¹

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Analytische Methoden zur Prüfung gesundheitsschädlicher Arbeitsstoffe: Analysen in biologischem Material , 14. Lieferung, Ausgabe 2000 Der Artikel enthält folgende Kapitel: Grundlage des Verfahrens Geräte, Chemikalien und Lösungen Geräte Chemikalien Lösungen Vergleichsstandards Probenahme und Probenaufbereitung Gaschromatographische Arbeitsbedingungen Analytische Bestimmung Kalibrierung Berechnung des Analysenergebnisses Standardisierung der Messergebnisse und Qualitätssicherung Beurteilung des Verfahrens Präzision Richtigkeit Nachweisgrenze Störeinflüsse Diskussion der Methode

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Stoffmonographie Pentachlorphenol-Referenz- und Human-Biomonitoring-Werte (HBM)

Cited by 21 publications

References 46 publications

Concept for the Evaluation of Carcinogenic Substances in Population-Based Human Biomonitoring

Concept for the Evaluation of Carcinogenic Substances in Population-Based Human Biomonitoring

Pentachlorphenol [Biomonitoring Methods in German language, 1999]

Pentachlorphenol [Biomonitoring Methods in German language, 2000]

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