Stoffwechselveränderungen in Erythrozyten bei der autoimmunen hämolytischen Krankheit

Red Cell Metabolism in Anaemia

“…This investigation confirms and extends previously reported results [2,3,13,18,20] that red cell 0 2 uptake in the presence of MB is increased in anaemia. The difference from normal was significant for the groups of thalassaemias, iron-deficiency anaemia, autoimmune haemolytic anaemias and chronic renal insufficiency.…”

“…O ka and Puranen [13] in 30 unselected cases of anaemia have found that this red cell metabolic activity was higher than normal and was correlated with the haemo globin level but not with the number of reticulocytes, that are known to display a higher Oa uptake in the presence of MB than old erythro cytes [6]. Brabec et al [2,3] reported a significantly higher than normal mean value in a group of 22 patients suffering from auto immune haemolytic anaemias and normal or slightly increased values in 6 cases of paroxysmal nocturnal haemoglobinuria (PNH). Similar results were obtained in this laboratory in 51 cases of autoimmune haemolytic anaemias [20] and in 3 cases of PNH [18].…”

A Review: Human Erythrocyte Acetylcholinesterase

“…Moderate reduction in activity has also been reported in some individuals with autoimmune hemolytic anemia [10,18,49,93,97,104,108]. Sirchia et al [97] found an association between diminished enzyme activity and the types of globulins coating the erythrocytes.…”

The Effect of Anti A Antibody on Red Cell Organic Phosphates and Adenosine Triphosphatase Activity in vitro

“…On the other hand, Jandl (1965b) failed to demonstrate any changes in glucose consumption, lactate formation, pentose phosphate pathway activity, glutathione content and level and exchange of cations in red cells exposed to anti A sera, anti D sera or sera from patients with high titer of autoantibody in amounts known to cause haemolysis in vivo, despite the presence of complement. Also Brabec et al (1965) and Busch & Schubothe (1963) did not find any changes in glycolysis, adenine nucleotides content, 2,3-diphosphoglycerate, GSH, nicotinamid adenine dinucleotide (NAD) and nicotinamid adenine dinucleotide phosphate (NADP) in autoimmune haemolytic anaemia, except the changes due to the increase in number of young red cells in the peripheral blood.…”

“…The latter authors have described diminished glycolytic activity even in red cells of erythroblastosis fetalis due to anti D antibodies. Tanaka et al (1964) and Brabec et al (1965) have reported decreased red cell acetylcholinesterase activity in autoimmune haemolytic anaemia and Kaplan et al (1964) have found a decrease in this enzyme in some cases of erythroblastosis fetalis due to antibodies in the ABO system. Goldstein & Desforges (1965) have Palek, MirEevovB, Brabec, Friedmann & Mhjskf observed increased loss of potassium from Cmmbs-positive red cells.…”