Stoffwechselvorg�nge im Gehirn bei akuter Anoxie, akuter Isch�mie und in der Erholung

Thorn, W.; Pfleiderer, G.; Frowein, R. A.; Ross, I. Clunies

doi:10.1007/bf00364124

Cited by 177 publications

(9 citation statements)

References 59 publications

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“…Similar changes occur in the brains of intact newborn [6] and 10-day-old mice during anoxia and in those of adult mice [3]. T h e mechanism of the increase in glycolysis in anoxic brain, the so-called "Pasteur effect," is now well understood [l, 2,[11][12][13]. T h e profound reduction of brain glucose concentration during acute anoxia in young mice is not reflected in, nor a reflection of, reduced levels of glucose in the blood.…”

Section: Discussionmentioning

confidence: 86%

Anoxia in Mice: Reduced Glucose in Brain with Normal or Elevated Glucose in Plasma and Increased Survival after Glucose Treatment

1974

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Survival after 5 min of anoxia in 39 controls (8-12-day-old mice) was only 5% compared with 82y0 in 39 glucose-treated littermates. Even after decapitation there was a delay in the onset of terminal gasping in the isolated heads of glucose-treated animals (P = 0.03) and the last gasp occurred much later than in the heads of control animals ( P < 0.001). To study the mechanism of this phenomenon mice were injected with 30 mmol/kg glucose subcutaneously. Control animals were given equiosmolal amounts of NaC1. One hour later the animals were exposed to nitrogen gas (0 pressure < 5 mm Hg). In glucose-treated mice the initial glucose concentration in brain was 3 times the control value ( P < 0.001). ATP, P-creatine, and glycogen levels were unchanged.Although the rate of use of these compounds during anoxia was similar in both groups of mice, the high level of glucose in brain in glucose-treated mice permitted considerable sparing of these energy-yielding metabolites. In terms of actual and potential molar equivalents of high energy phosphate (NP), the brain energy reserve after 4 min of anoxia in glucose-treated animals was twice that of controls, 10.70 =t 0.72 versus 4.75 =t 1.19 mmol/kg ( P = 0.009). SpeculationDuring acute anoxia, concentration of glucose in brains of young animals is critically reduced, although levels of glucose in plasma remain normal or may even become elevated. Pretreatment or concurrent administration of glucose increases anoxic survival. Because glucose has this dramatic life-saving effect in anoxic animals, the possibility that inadequate brain glucose supplies may occur in anoxic man in the face of normal or elevated levels of glucose in plasma should be considered. Introductionglucose in brain fell 80% and 60%, respectively [lo],

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Section: Discussionmentioning

confidence: 86%

Anoxia in Mice: Reduced Glucose in Brain with Normal or Elevated Glucose in Plasma and Increased Survival after Glucose Treatment

1974

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“…Der Gehalt an Fructose-l,6-Diphosphat mit 0,2gMol zeigt an, dab sich das Gewebe auf anaerobe Glykolyse umstellt [28].…”

Section: Versuchsprogrammunclassified

“…Geht man davon aus, dab bei der Pr~i-paration glykogenhaltige Myofibrillen miterfaBt werden, so liegt der Glykogengehalt niedrig und gleicht dem des Zentralnervensystems und sonstiger Ganglien [28].…”

Section: Versuchsprogrammunclassified

Glykogengehalte, glykolytische Aktivität und Metabolitgehalte im Atrioventricularsystem des Rinderherzens

Thorn

Nitsche²,

Harms

et al. 1978

Res. Exp. Med.

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In the atrioventricular system (AVS) consisting of the compact node, the penetrating bundle and the branching bundles of about 250 bovine hearts there were made several studies: 1. In quickly removed and fixed specimens (distal AV-node, penetrating bundle) determination of a metabolic state with respect to glycogen, glucose, lactate, ATP, ADP, AMP, creatinephosphate, total creatine, gluc-6-phosphate, fructose-6-phosphate, fructose-1,6-diphosphate, dihydroxyacetonphosphate and pyruvate. 2. Determination of glycogen contents and glygolytic activity in AVS and its parts for ischemic times up to three hours. 3. The determination of metabolic contents in samples of connective tissue in atrium and ventricle of bovine hearts. The AV-nodes are poor in glycogen comparable with glycogen content of central nervous system and other ganglia. Penetrating bundles of Hiss and branching bundle belong after liver to the glycogen richest parenchyma of animal tissues. Even after ischemia of 3 h only a part of glycogen was recovered as lactate. The greater part of glycogen must be considered as a structural element of Hiss bundle and branching bundles of the ventricles.

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“…Daß das Ausweichen auf den zwar substratintensiven aber sauer stoffunabhängigen Weg der Energiegewinnung tatsächlich realisiert wird, ist für das Hirngewebe [5,10,39] und für den Herzmuskel [9,27,40] nachgewiesen. In diesem Mechanismus ist auch die E rklä rung für Beobachtungen von Daives, Mott und Shelley [3] an Neuge borenen verschiedener Tierarten zu suchen, daß ihre Überlebenszeit bei reiner N 2-Atmung in direkter Beziehung steht zu dem Glykogen gebalt ihres Herzmuskels.…”

Section: Diskussionunclassified

Untersuchungen über das Verhalten des fetalen Blutzuckerspiegels unter der Geburt

Schönfelder¹

1965

Gynecol Obstet Invest

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Stoffwechselvorg�nge im Gehirn bei akuter Anoxie, akuter Isch�mie und in der Erholung

Cited by 177 publications

References 59 publications

Anoxia in Mice: Reduced Glucose in Brain with Normal or Elevated Glucose in Plasma and Increased Survival after Glucose Treatment

Anoxia in Mice: Reduced Glucose in Brain with Normal or Elevated Glucose in Plasma and Increased Survival after Glucose Treatment

Glykogengehalte, glykolytische Aktivität und Metabolitgehalte im Atrioventricularsystem des Rinderherzens

Untersuchungen über das Verhalten des fetalen Blutzuckerspiegels unter der Geburt

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