Stoichiometric model of α-cyclodextrin complex formation

Prediction of Binding Constants of α-Cyclodextrin Complexes

“…This comparison reveals that the cinnamic acid COOH group has the polarity of an aromatic carboxylic acid, and therefore that it is to be counted in the quantity -∆A, which becomes 125 for cinnamic acids (which are thought to have the -CHdCHCOOH moiety inserted in the cavity). 20,21 The polarity of the -NdN-group as it appears in phenylazobenzenes and naphthylazobenzenes can be evaluated in this way: The experimental log P for 4-(dimethylamino)-azobenzene is 4.58, whereas the sum of the fragmental constants, omitting only the azo group, is 3.96. The difference, +0.62, is attributed to the azo group, which therefore is nonpolar by our criterion.…”

Potentiometric Study of Molecular Complexes of Weak Acids and Bases Applied to Complexes of α-Cyclodextrin with para -Substituted Benzoic Acids

“…These moments are, for X = COCH3,3.00 D; CN, 4.39; and NOz, 4.21 (21). An increase in site polarity will tend to decrease the site binding constant (20), and both Kllb and K1za may reflect this effect superimposed on the electron density effect.…”

The Stability of Cyclodextrin Complexes in Solution

“…Higher stoichiometric ratios are possible but will not be considered here. The development used for case (a) 130 leads to eq 16 for the stepwise constant K 11 , where b XY ) K* X′Y′ /K X′Y ) K** X′Y′ /K X′Y′ . Equation 16 is very interesting, especially in those instances in K 11 ) 2K X′X (10)…”

“…Binding Constants for r-Cyclodextrin Complexes with Substrates Containing the trans-Cinnamoyl Group130 …”