Stomach cancer screening and preventive behaviors in relatives of gastric cancer patients

Kang, Jung Min; Shin, Dong Wook; Kwon, Young Min; Park, Sang Min; Park, Min Sun; Park, Jin Ho; Son, Ki Young; Cho, Belong

doi:10.3748/wjg.v17.i30.3518

Cited by 22 publications

(24 citation statements)

References 34 publications

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“…A recent meta-analysis of five studies showed that family history can exert beneficial effects in gastric cancer patients [77]. Subjects undertake frequent health screenings due to their family history of gastric cancer [78], show good health-related behaviors, such as non-smoking, non-alcoholic drinking and consistent exercise, and frequently have microsatellite instability and mismatch repair proteins, which are associated with a good prognosis [73]. …”

Section: Effect Of Family History On the Outcome Of Gastric Cancermentioning

confidence: 99%

Gastric cancer and family history

Choi

Kim

2016

Korean J Intern Med

136

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Gastric cancer is associated with high morbidity and mortality rates worldwide. Identifying individuals at high risk is important for surveillance and prevention of gastric cancer. Having first-degree relatives diagnosed with gastric cancer is a strong and consistent risk factor for gastric cancer, but the pathogenic mechanisms behind this familial aggregation are unclear. Against this background, we reviewed the risk factors for gastric cancer in those with a first-degree relative with gastric cancer, and the possible causes for familial clustering of gastric cancer including bacterial factors, inherited genetic susceptibility, environmental factors or a combination thereof. Among individuals with a family history, current or past Helicobacter pylori infection, having two or more first-degree affected relatives or female gender was associated with an increased risk of developing gastric cancer. To date, no specific single nucleotide polymorphism has been shown to be associated with familial clustering of gastric cancer. H. pylori eradication is the most important strategy for preventing gastric cancer in first-degree relatives of gastric cancer patients, particularly those in their 20s and 30s. Early H. pylori eradication could prevent the progression to intestinal metaplasia and reduce the synergistic effect on gastric carcinogenesis in individuals with both H. pylori infection and a family history. Endoscopic surveillance is also expected to benefit individuals with a family history. Further large-scale, prospective studies are warranted to evaluate the cost-effectiveness and optimal time point for endoscopy in this population. Moreover, genome-wide association studies that incorporate environmental and dietary factors on a ‘big data’ basis will increase our understanding of the pathogenesis of gastric cancer.

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Section: Effect Of Family History On the Outcome Of Gastric Cancermentioning

confidence: 99%

Gastric cancer and family history

Choi

Kim

2016

Korean J Intern Med

136

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“…Such a system may be particularly useful in identifying early gastric cancer where endoscopic findings are unreliable and histological analysis may not distinguish gastric-type differentiated lesions from regenerative or inflammatory changes. First-degree relatives (FDRs) of gastric cancer patients are considered to be at risk of developing future disease, presumably due to a genetic susceptibility and possibly due to common environmental exposures [6][7][8][9]. The mucin phenotype of the gastric mucosa in healthy FDRs has not been studied.…”

Section: Introductionmentioning

confidence: 99%

Gastric mucin expression in first-degree relatives of gastric cancer patients

Boltin

Gingold‐Belfer²,

Dickman³

et al. 2014

European Journal of Gastroenterology &Amp; Hepatology

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“…Modifications in high risk behavior is essential in primary prevention of gastric cancer (Kang et al, 2011 ). Many studies have demonstrated an association between unhealthy food (i.e.…”

Section: Discussionmentioning

confidence: 99%

A Registry Program for Familial Gastric Cancer Patients Referred to Cancer Institute of Iran

Etemadi¹,

Pourian²,

Shakib³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Gastric cancer is the second most common cause of cancer death. It has a poor prognosis with only 5-10% of hereditary etiology. If it is diagnosed, it could be helpful for screening the other susceptible members of a family for preventive procedures. Usually it is identified by symptoms such as presence of cancer in different members of family, some special type of pathology such as diffused adenocarcinoma, having younger age and multiple cancer syndromes. Hence, designing a registry program can be a more practical way to screen high risk families for a preventive program. Materials and Methods: Based on the inclusion criteria, a questionnaire was prepared. After pilot on a small number of patients, the actual data was collected from 197 patients and processed in SPSS 16.0. Results: Totally, 11.8% of the patients were younger than 45 years old. Blood type 'A' was dominant and males had a higher risk behavior with higher consumption of unhealthy food. Adenocarcinoma was reported in majority of cases. 21.8% of the patients had the including criteria for familial gastric cancer (FGC). Conclusions: The high percentage of FGC population compared to the other studies have revealed a need to design an infrastructural diagnostic protocol and screening program for patients with FGC, plus preventive program for family members at risk which could be done by a precise survey related to frequency and founder mutations of FGC in a national registry program.

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Stomach cancer screening and preventive behaviors in relatives of gastric cancer patients

Abstract: The gastric cancer screening and preventive behaviors of GCRs have yet to be improved. To increase awareness among GCRs, systematic family education programs should be implemented.

Cited by 22 publications

References 34 publications

Gastric cancer and family history

Gastric cancer and family history

Gastric mucin expression in first-degree relatives of gastric cancer patients

A Registry Program for Familial Gastric Cancer Patients Referred to Cancer Institute of Iran

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