Stool antigen detection versus  13 C-urea breath test for non-invasive diagnosis of pediatric  Helicobacter pylori  infection in a limited resource setting

El-Shabrawi, Mortada; El-Aziz, Nabil Abd; El-Adly, Tarek Zakaria; Hassanin, Fetouh; Eskander, Ayman; Abou-Zekri, Maha; Mansour, Hala A.; Meshaal, Safa

doi:10.5114/aoms.2016.61031

Cited by 30 publications

(31 citation statements)

References 24 publications

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“…In other hand, Sykora [20] found the prevalence of H. pylori infection in asymptomatic children in the Czech Republic at a rate of 7%. Recent studies conducted by several researchers reported different ranges of H. pylori infection; Daugule et al, [221] in Latvia confirmed that (17.7%) of the total 220 patient samples was positive to SAT; in Korea Moon et al, [22] reported that from 318 seropositive subjects, 256 (80.5%) showed positive stool test; El-shabrawi et al, [23] in Egypt, reported that the H. pylori SAT test was positive in 34 (89.5%) out of the 38 patients.…”

Section: Prevalence Of H Pylori In Females According To Habitation Sitementioning

confidence: 99%

Application of Stool Antigen Test for Monitoring Helicobacter Pylori Among Human in Erbil Governorate, Kurdistan Region/Iraq

Almashhadany¹

2018

Int J Pharm Pharm Sci

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Objective: This work was connected to screen Helicobacter pylori among human in Erbil Governorate by using stool antigen test (SAT).Methods: In a clean and sterile container, three hundred stool samples were collected from both sexes during the period from July-December 2017. Samples were collected from 150 males at the rural and an urban area in equal number, similarly 150 females same areas. The collected samples were tested in Microbiology Laboratory, Department of Pathological Analysis using One-Step H. pylori Antigen Test Kit.Results: The obtained results shown that the prevalence of H. pylori in total samples were (11.3%). The rate of infection among females were (12.7%) compared to (10.0%) of male infection rate. According to the age wise of the patients (11-20, 51-60 and above 60 y) results showed that the H. pylori antigen rates were (16.3%, 11.9%, and 13.6%) respectively that mean the high rate of infection was varied. According to habitation, the high rate of H. pylori among males was 12.0% and 8.0% in rural and urban area consecutively. While the occurrence rate of H. pylori antigen among female was high 14.7% in rural area, compared to 10.7% in the female of the urban area. The proportion of H. pylori antigen rate in September, December and October were (16.0%, 14.0%, and 12.0%) respectively.Conclusion: From this study, we concluded that the prevalence of H. pylori among human in Erbil Governorate was high, and the infection takes place in the early years of life. The significance of public health risks was discussed.

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Section: Prevalence Of H Pylori In Females According To Habitation Sitementioning

confidence: 99%

Application of Stool Antigen Test for Monitoring Helicobacter Pylori Among Human in Erbil Governorate, Kurdistan Region/Iraq

Almashhadany¹

2018

Int J Pharm Pharm Sci

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“… 24 The reduction a dose of 50 mg in children was found in several studies that have been used to diagnose H. pylori infection. 22 , 25 At the same dose of 13 C-urea, low production of endogenous CO 2 in younger children has a relatively high isotope ratio of 13 CO 2 to 12 CO 2 . 25 However, in Indonesia we use a similar dose for adults and children.…”

Section: Urea Breath Testmentioning

confidence: 99%

Noninvasive Helicobacter pylori Diagnostic Methods in Indonesia

Miftahussurur

2020

Gut and Liver

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Although the prevalence of Helicobacter pylori infection in Indonesia is lower than that in other countries, H. pylori is still an essential pathogen associated with severe gastric mucosal damage and dyspeptic symptoms. Invasive diagnostic methods are not ideal due to the lack of endoscopic centers and high costs without full coverage by social insurance. Among the noninvasive methods, the urea breath test is widely available in Indonesia and has been suggested as the primary option to ensure the successful eradication of H. pylori. There has been no local validation for the urea breath test utilizing 13 C or 14 C. The stool antigen test is inexpensive and suitable for use in active infections before and after eradication; however, customs and habits are obstacles to delivering fresh stool on time. Only polyclonal antibodies and qualitative stool antigen test kits with low sensitivity are available. Serology is a widely validated method and has good accuracy, but it cannot distinguish between active and inactive infections. According to our observations, serology is the main choice of experts and patients, as it is simple, inexpensive and widely known. The urine test is an alternative for reducing costs and endoscopic workload, with high accuracy but low sensitivity. Further studies are necessary to prove the validity of the urine test to be used throughout Indonesia, especially in areas with a low prevalence of H. pylori infection. In conclusion, the validated urea breath test and the stool antigen test are considered noninvasive practical approaches for the detection of H. pylori infection in Indonesia, with serological and urine tests as alternatives.

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“…Development of an accurate rapid SAT could make diagnosis of the infection easier and cheaper, especially for low‐income countries; therefore, studies evaluated the accuracy of fast SATs in different settings. A rapid lateral flow one‐step H. pylori SAT was evaluated against UBT in 60 symptomatic children (mean age 7.2 years), showing a rather good overall accuracy of 91.7% . Although the sensitivity, specificity, and positive predictive value were 89.5% (95% CI: 75.2‐97.1), 95.5% (95% CI: 77.2‐99.9), and 97.1% (95% CI: 85.1‐99.9), respectively, the negative predictive value was only 84% (95% CI: 63.9‐95.5).…”

Section: Diagnosismentioning

confidence: 99%

Helicobacter pyloriand some aspects of gut microbiota in children

2018

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Helicobacter pylori infection in children differs from infection in adults in many aspects. The rate of infection, epidemiology, clinical presentations and complications, the applicability of diagnostic tests, antibiotic resistance, treatment options, and success rates differ significantly. Due to all these differences, management guidelines for children and adults differ also substantially. In 2017, the Updated ESPGHAN and NASPGHAN Guidelines on the management of H. pylori infection in children were published, emphasizing the differences in clinical presentation and indications for treatment, stating that the primary goal of clinical investigation in children is to identify the cause of upper gastrointestinal symptoms rather than the presence of H. pylori infection. Therefore, the diagnosis should be based on upper endoscopy, and the "test and treat strategy" should not be used in children. Due to an increasing rate of antibiotic resistance worldwide, the updated guidelines recommend broader use of antimicrobial susceptibility testing for H. pylori strains in order to tailor eradication treatment accordingly. Moreover, treatment in children should be prescribed only when indicated and should be based on the rate of eradication in local populations aiming for treatment success above 90%. During the last two decades there has been a steady decrease in the rate of H. pylori infection in both children and adults in the Western world. Two recent publications studying the incidence of H. pylori infection confirmed that early childhood is a time for acquisition of infection both in industrialized and nonindustrialized countries. In addition, they showed that H. pylori could be acquired outside the family. In respect to the inverse association between H. pylori and allergy, a longitudinal study demonstrated that early exposure to H. pylori at any age was inversely associated with atopy and allergic conditions.

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Stool antigen detection versus 13 C-urea breath test for non-invasive diagnosis of pediatric Helicobacter pylori infection in a limited resource setting

Cited by 30 publications

References 24 publications

Application of Stool Antigen Test for Monitoring Helicobacter Pylori Among Human in Erbil Governorate, Kurdistan Region/Iraq

Application of Stool Antigen Test for Monitoring Helicobacter Pylori Among Human in Erbil Governorate, Kurdistan Region/Iraq

Noninvasive Helicobacter pylori Diagnostic Methods in Indonesia

Helicobacter pyloriand some aspects of gut microbiota in children

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