Stop the crop: Insights into the insecticidal mode of action of cinnamodial against mosquitoes

Kalsi, Megha; Walter, Anton; Lee, Beenhwa; DeLaat, Andrew; Trigueros, Renata Rusconi; Happel, Katharina; Sepesy, Rose; Nguyen, Bao; Manwill, Preston K.; Rakotondraibe, Liva Harinantenaina; Piermarini, Peter M.

doi:10.1016/j.pestbp.2020.104743

Cited by 1 publication

(1 citation statement)

References 42 publications

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“…The chemical activators group is divided in turn into two subgroups depending on the origin of the activator/modulator: exogenous and endogenous. Exogenous stimuli are capsaicin [ 38 ] and its antagonist capsazepine [ 39 ], resiniferatoxin (RTX) [ 37 , 40 ], bradykinin [ 41 ], yohimbine [ 42 ], ethanol [ 43 ], evodiamine [ 44 ], 17-β-estradiol [ 45 ], quinazoline [ 46 ], progesterone [ 47 ], numerous opioids [ 48 ], nicotine [ 49 ], hyaluronan [ 50 ], insulin [ 51 ], tinyatoxin [ 52 ], olvanil [ 53 ], acetylsalicylic acid [ 54 ], eugenol [ 55 ], sesquiterpenes [ 56 , 57 , 58 ], cannabidiol [ 59 ], prenylphenols [ 60 ], zingerone [ 61 ], shogaol [ 61 ], PPAHV [ 62 ], gingerol [ 63 ], numerous pharmacological antagonists [ 64 , 65 , 66 , 67 ], and peptide toxins from different species [ 4 , 68 ]. Endogenous activators comprise numerous compounds [ 1 ], such as the wide family derived from polyunsaturated fatty acids (PUFAs).…”

Section: Figurementioning

confidence: 99%

Role and Modulation of TRPV1 in Mammalian Spermatozoa: An Updated Review

Ramal-Sanchez

Bernabò

Valbonetti

et al. 2021

IJMS

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Based on the abundance of scientific publications, the polymodal sensor TRPV1 is known as one of the most studied proteins within the TRP channel family. This receptor has been found in numerous cell types from different species as well as in spermatozoa. The present review is focused on analyzing the role played by this important channel in the post-ejaculatory life of spermatozoa, where it has been described to be involved in events such as capacitation, acrosome reaction, calcium trafficking, sperm migration, and fertilization. By performing an exhaustive bibliographic search, this review gathers, for the first time, all the modulators of the TRPV1 function that, to our knowledge, were described to date in different species and cell types. Moreover, all those modulators with a relationship with the reproductive process, either found in the female tract, seminal plasma, or spermatozoa, are presented here. Since the sperm migration through the female reproductive tract is one of the most intriguing and less understood events of the fertilization process, in the present work, chemotaxis, thermotaxis, and rheotaxis guiding mechanisms and their relationship with TRPV1 receptor are deeply analyzed, hypothesizing its (in)direct participation during the sperm migration. Last, TRPV1 is presented as a pharmacological target, with a special focus on humans and some pathologies in mammals strictly related to the male reproductive system.

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