Pomegranate seed oil (PSO) has exceptional nutritional value due to high amounts of punicic acid, an essential and polyunsaturated fatty acid (18:3 cis-9, trans-11, cis-13) and conjugate of α-linolenic acid (Aruna et al., 2018;Fawole & Opara, 2018). An increasing number of in vitro and in vivo investigations have implicated the bioactive lipid compound to biological properties such as antidiabetic, antiobesity, antiproliferative, and anticarcinogenic activity against various forms of cancers (Aruna et al., 2016;Lansky and Newman, 2007). Besides, other bioactive compounds such as phytosterols, tocopherols, carotenoids, and polyphenols can be found