Storage stability of formaldehyde solutions containing pararosaniline reagent

Georghiou, Paris E.; Winsor, Linda; Shirtliffe, Cliffe J.; Svec, J.

doi:10.1021/ac00146a024

Cited by 10 publications

(1 citation statement)

References 25 publications

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“…Early studies disclosed that spectrophotometric [14,15] or electrochemical methods [16] often suffer from several environmental interferences, [17] measurements by different methods result in different values for the concentration of exogenous and endogenous formaldehyde. To reduce these interferences, according to the universal principle, pre-column derivatization was regarded as a promising solution for high-performance liquid chromatography (HPLC) method with diode-array detection (DAD) to identify and quantify formaldehyde (FA), [18] formaldehyde was quantified with DAD after derivatization with ethyl 3-oxobutanoate and ammonia to yield the diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate.…”

Section: Introductionmentioning

confidence: 99%

2,4-Dinitrophenylhydrazine Pre-column Derivatization: High Performance Liquid Chromatography Determination of Residual Formaldehyde in Pharmaceutical Industry and Key Parameters Analysis

Yin,

Sheng

2024

Med. Res.

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Formaldehyde is a colorless gas with a pungent odor, and it is commonly used in many industries to produce resins, plastics, textiles, household products, as well as pharmaceutics. Accurate formaldehyde analysis is significant for environmental and industrial control. In this paper, formaldehyde is analyzed as its 2,4-dinitrophenylhydrazine derivative through a high performance liquid chromatography method. The method has been validated for specificity, limit of detection, limit of quantification, linearity and range, precision, accuracy, and solution stability, which showed simplicity, speed, and accuracy, making it well-suited for the determination of traceable levels of formaldehyde in the pharmaceutical industry.

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