Store and Prescription Characteristics Associated with Primary Medication Nonadherence

Jackson, Tristen; Bentley, John P.; McCaffrey, David J.; Pace, Pat; Holmes, Erin R.; West-Strum, Donna

doi:10.18553/jmcp.2014.20.8.824

Cited by 21 publications

(34 citation statements)

References 11 publications

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“…Of the 33 articles, 28 were observational studies and five were controlled trials . Five studies were conducted in Europe, and the remaining were conducted in the United States or Canada .…”

Section: Resultsmentioning

confidence: 99%

Prevalence of and factors associated with primary medication non‐adherence in chronic disease: A systematic review and meta‐analysis

et al. 2019

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Background: Primary medication non-adherence (PMN), defined as failure to obtain newly prescribed medications, results in adverse clinical and economic outcomes.We aimed to (a) assess the prevalence of PMN in six common chronic diseases: asthma and/ or chronic obstructive pulmonary disease, depression, diabetes mellitus, hyperlipidaemia, hypertension and osteoporosis; (b) identify and categorise factors associated with PMN; (c) explore characteristics that contributed to heterogeneity between studies. Methods:We performed a systematic search in MEDLINE, Embase, Cochrane Library, CINAHL and PsycINFO. Studies published in English between January 2008 and August 2018 assessing PMN in subjects aged ≥18 years were included. We used the Cochrane risk of bias tool, Newcastle-Ottawa Scale and National Heart, Lung and Blood Institute Quality Assessment Tool to assess the quality of randomised controlled trials, cohort and cross-sectional studies, respectively. Findings were reported using the PRISMA checklist. PMN rates were pooled using a random effects model. We summarised factors associated with PMN descriptively. Subgroup analysis was performed to explore sources of heterogeneity. Results:We screened 3083 articles and included 33 (5 randomised controlled trials, 26 cohort and 2 cross-sectional studies, n = 539 156), of which 31 (n = 519 971) were used in meta-analysis. The pooled PMN rate was 17% (95% CI: 15%-20%). Pooled PMN rates were highest in osteoporosis (25%, 95% CI: 7%-44%) and hyperlipidaemia (25%, 95% CI: 18%-32%) and lowest in diabetes mellitus (10%, 95% CI: 7%-12%).Factors commonly associated with PMN include younger age, number of concurrent medications, practitioner specialty and higher co-payment. Type of chronic disease, age, study setting and PMN definition contributed to heterogeneity between studies (all P < 0.001). Conclusion:Primary medication non-adherence is common among patients with chronic diseases and more needs to be done to address this issue in order to improve patient outcomes. Future PMN studies could benefit from greater standardisation to enhance comparability.

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Section: Resultsmentioning

confidence: 99%

Prevalence of and factors associated with primary medication non‐adherence in chronic disease: A systematic review and meta‐analysis

et al. 2019

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“…This sample population reported nonadherence to newly prescribed medications that parallel findings from other published studies. 39,40 Yet, pharmacists are in a unique position to help these patients overcome adherence-related barriers to improve health-related outcomes.…”

Section: ■■ Discussionmentioning

confidence: 99%

Understanding Reasons for Nonadherence to Medications in a Medicare Part D Beneficiary Sample

Hincapie

Taylor

Boesen³

et al. 2015

JMCP

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“…6, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32 Reflecting this perspective, a multilevel approach to medication nonadherence is novel,15, 33 as multilevel medication nonadherence factors have received little attention in transplantation 6, 11, 13, 14, 34. Should this new perspective reveal independent multilevel immunosuppressant nonadherence correlates, addressing such correlates would demand interventional approaches targeting not only patients but healthcare workers/family, organizations, and policymakers 6, 21, 24…”

Section: Introductionmentioning

confidence: 99%

Multilevel factors are associated with immunosuppressant nonadherence in heart transplant recipients: The international BRIGHT study

Denhaerynck

Berben

Dobbels

et al. 2018

American Journal of Transplantation

100

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Factors at the level of family/healthcare worker, organization, and system are neglected in medication nonadherence research in heart transplantation (HTx). The 4‐continent, 11‐country cross‐sectional Building Research Initiative Group: Chronic Illness Management and Adherence in Transplantation (BRIGHT) study used multistaged sampling to examine 36 HTx centers, including 36 HTx directors, 100 clinicians, and 1397 patients. Nonadherence to immunosuppressants—defined as any deviation in taking or timing adherence and/or dose reduction—was assessed using the Basel Assessment of Adherence to Immunosuppressive Medications Scale© (BAASIS ©) interview. Guided by the Integrative Model of Behavioral Prediction and Bronfenbrenner's ecological model, we analyzed factors at these multiple levels using sequential logistic regression analysis (6 blocks). The nonadherence prevalence was 34.1%. Six multilevel factors were associated independently (either positively or negatively) with nonadherence: patient level: barriers to taking immunosuppressants (odds ratio [OR]: 11.48); smoking (OR: 2.19); family/healthcare provider level: frequency of having someone to help patients read health‐related materials (OR: 0.85); organization level: clinicians reporting nonadherent patients were targeted with adherence interventions (OR: 0.66); pickup of medications at physician's office (OR: 2.31); and policy level: monthly out‐of‐pocket costs for medication (OR: 1.16). Factors associated with nonadherence are evident at multiple levels. Improving medication nonadherence requires addressing not only the patient, but also family/healthcare provider, organization, and policy levels.

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Store and Prescription Characteristics Associated with Primary Medication Nonadherence

Cited by 21 publications

References 11 publications

Prevalence of and factors associated with primary medication non‐adherence in chronic disease: A systematic review and meta‐analysis

Prevalence of and factors associated with primary medication non‐adherence in chronic disease: A systematic review and meta‐analysis

Understanding Reasons for Nonadherence to Medications in a Medicare Part D Beneficiary Sample

Multilevel factors are associated with immunosuppressant nonadherence in heart transplant recipients: The international BRIGHT study

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