Storiform-Pleomorphic Type of Multifocal Malignant Fibrous Histiocytoma of the Lumbar Spine

Abstract

Patient: Male, 67Final Diagnosis: Malignant fibrous histiocytomaSymptoms: Back pain • leg weakness • weight lossMedication: —Clinical Procedure: —Specialty: —Objective:Rare diseaseBackground:We present the extremely rare case of a 67-year-old male with malignant fibrous histiocytoma, arising in the lumbar spine, demonstrated with radiological and pathological studies.Case Report:The patient and his relatives refused open surgical approach and we performed transpedicular vertebral corpus biopsy and vertebroplasty under spinal anesthesia. His pathological result was malignant fibrous histiocytoma. The spine is a very uncommon site for malignant fibrous histiocytoma.Conclusions:The management of malignant fibrous histiocytoma relies on the combination of maximum decompression surgery, chemotherapy and radiotherapy. Total removal is unrealistic and diagnosis is difficult. The prognosis in terms of continuing neurological deficit after surgery appears to be poor.

Establishment of a patient-derived xenograft mouse model of pleomorphic leiomyosarcoma

“…Although pleomorphic and conventional leiomyosarcomatous areas are typically intermixed within a tumor, the demarcation may be distinct or gradual in some cases 14 . Furthermore, it has been reported that PLMS contain myxoid or focally collagenous stroma, which resemble those of storiform-pleomorphic undifferentiated sarcomas 15 . The characteristics of the PDX in our model were closely comparable to the typical characteristics of PLMS, thereby confirming the establishment of an original tumor-like PLMS PDX model.…”