STR Markers Unveil Microgeographic Differentiation over the Steep Mountainous Landscape of Jujuy Province, Northwest Argentina

Gómez-Pérez, Luis; Alfonso‐Sánchez, Miguel Á.; Dipierri, José Edgardo; Peña, José A.

doi:10.13110/humanbiology.88.3.0210

Cited by 3 publications

(10 citation statements)

References 39 publications

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“…The study of NRY markers highlighted a high Native American component in the paternal lineages, as can be inferred from the genetic affinity of Jujuy subpopulations with other South Amerindian samples from surrounding communities (see Figure ). Predominance of the Native American genetic background in Jujuy has been reported in previous works based on a variety of genetic markers: autosomal loci, such as immunoglobulin allotypes, serum polymorphisms (Dipierri et al, ), polymorphic Alu insertions (Gómez‐Pérez et al, ), STRs of human chromosome 6 (Gómez‐Pérez et al, ), and uniparentally inherited markers, such as Y‐STRs (Bianchi et al, ), Y‐chromosome haplogroups (Altuna et al, ; Ramallo et al, ), and mitochondrial DNA lineages (Cardoso et al, ). All these findings contribute pieces of evidence for the high degree of conservation of the Amerindian gene pool in the zone (Bailliet et al, ; Cardoso et al, ; Gómez‐Pérez et al, ).…”

Section: Discussionmentioning

confidence: 77%

“…The population from Jujuy has been reported to be almost entirely composed (98.3%) of Amerindian mtDNA haplogroups (Cardoso et al, ). The assessment of the contemporary paternal genetic landscape through the NRY markers revealed significant genetic heterogeneity between population centers located at the highest points of Jujuy and those demographic nuclei situated at lower altitudes, somehow corroborating the existence of two differentiated entities: Jujuy highlands and Jujuy lowlands, with notable differences between them in terms of the impact of external gene flow (Gómez‐Pérez et al, , ).…”

Section: Discussionmentioning

confidence: 84%

“…At the same time, the unequal impact of gene flow according to altitude would have resulted in variable genetic admixture rates across the province, as documented in some previously published articles (Dipierri et al, , ; Gómez‐Pérez et al, ). Geographic (steep orography) and socioeconomic (limited employment opportunities) features have been proposed as limiting factors for gene flow in the higher‐altitude zones (Gil, ; Gómez‐Pérez et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…Finally, samples from communities living at an altitude of more than 3500 m were included in the Puna sample (N = 19). A previous article by these authors Gómez‐Pérez et al () used the designation “Jujuy highlands” to refer a population cluster including pre‐Puna (Quebrada Alta and Quebrada Baja) and Puna regions, with an altitude range of between 2000 m and above 4300 m (N = 42). In this work we followed the same nomenclature and we also employed the term “Jujuy lowlands” hereafter to refer the population group formed by Selva and Valle, with an altitude range of 400 to 2000 m (N = 107).…”

Section: Methodsmentioning

confidence: 99%

“…The population census of 1778 already registered large differences in the proportions of Amerindians, Africans and Europeans between the different regions of the province (see Dipierri et al, ). At the same time, the steep orography of Jujuy could also have acted as a physical barrier to interregional migration among Jujuy's Native American communities (Cardoso et al, ; Gómez‐Pérez et al, ; Gómez‐Pérez, Alfonso‐Sánchez, Dipierri, & Peña, ).…”

Section: Introductionmentioning

confidence: 99%

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Paternal heritage in Jujuy province (Northwest Argentina): Evidence for sex‐biased gene flow and genetic drift effects

Alfonso‐Sánchez

Gómez-Pérez

Dipierri

et al. 2019

American J Hum Biol

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Objectives: This study aimed to explore the diversity of paternal lineages in Jujuy province (Argentina) by analyzing Y chromosome markers. Furthermore, we examined among-population genetic variability based both on paternally (NRY haplotypes) and maternally (mtDNA haplogroups) inherited markers. We sought to evaluate the impact of sex-biased gene flow on genetic background in Jujuy, and contribute data on the microevolutionary forces acting in this zone. Methods: DNA from 149 males from five Jujuy regions were analyzed for 12 nonrecombining Y (NRY) markers. Genetic heterogeneity among Jujuy regions was evaluated through population differentiation tests. To identify potential genetic boundaries in Jujuy, analysis of molecular variance (AMOVA) and the Monmonier's algorithm implemented in the Barrier v2.2 software were employed. Results: A clear divergence between Jujuy highlands and lowlands for NRY haplotypes was found. A marked discrepancy between genetic structuring for paternal lineages and the lack of geographical pattern for mitogenomes was confirmed by all statistical analyses. Conclusions: Genetic structuring of paternal lineages is most likely caused by admixture processes that have occurred since colonial times in the Jujuy lowlands.Immigrants were predominantly male that settled in the lower altitude zones, due to the steep orography of the region. Input of allochthonous male lineages because of gene flow toward the lowlands would have increased diversity of NRY markers, thus compensating for drift effects. Likewise, limited input of allochthonous mitogenomes would have promoted genetic drift, a key factor in the shaping of diversity of maternal lineages across Jujuy subpopulations, irrespective of altitude.

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Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Paternal heritage in Jujuy province (Northwest Argentina): Evidence for sex‐biased gene flow and genetic drift effects

Alfonso‐Sánchez

Gómez-Pérez

Dipierri

et al. 2019

American J Hum Biol

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Newborn anthropometry, maternal capital, and altitude in the highland population from the province of Jujuy, Argentina

Martínez

Figueroa

Gómez

et al. 2020

American J Phys Anthropol

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Objective To analyze variability in newborn (NB) anthropometry among Jujenean NBs as a function of geographic altitude (500 m to ≈4000 masl), maternal anthropometry and other maternal characteristics within the maternal capital framework. Materials and methods Data obtained from 41,371 mother/child pairs recorded in the Jujuy Perinatal Information System (SIP) between 2009 and 2014, including: NB and maternal weight, length/height and BMI; gestational age (corrected); maternal age, educational level, nutritional status, and marital status; birth interval; and planned pregnancy. Based on the declared place of residence, the prevalence of unsatisfied basic needs (% UBN) was determined and the data was split into two altitudinal groups: highlands (HL, >2500 masl) and lowlands (LL, <2500 masl). ANOVA, Chi‐squared and Pearson tests were applied as needed. Statistical associations between the response variables—NB weight, length and BMI—and maternal and environmental variables were tested using a Generalized Additive Mixed Model (GAMM). Results All NB and maternal anthropometric variables were lower in HL compared to LL; they also presented negative correlations with altitude, except NB length. Apart from gestational age and birth interval, HL and LL presented statistically significant differences in all study variables. GAMM results showed that maternal anthropometry was the main influence on NB weight and length. Discussion Of all the maternal capital features examined, only maternal anthropometric variables were found to protect offspring against the negative impact of HL environments.

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Birth Size and Maternal, Social, and Environmental Factors in the Province of Jujuy, Argentina

Martínez

Figueroa

Martínez-Carrión

et al. 2022

IJERPH

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Introduction: birth size is affected by diverse maternal, environmental, social, and economic factors. Aim: analyze the relationships between birth size—shown by the indicators small for gestational age (SGA) and large for gestational age (LGA)—and maternal, social, and environmental factors in the Argentine province of Jujuy, located in the Andean foothills. Methods: data was obtained from 49,185 mother-newborn pairs recorded in the Jujuy Perinatal Information System (SIP) between 2009 and 2014, including the following: newborn and maternal weight, length/height, and body mass index (BMI); gestational age and maternal age; mother’s educational level, nutritional status, marital status and birth interval; planned pregnancy; geographic-linguistic origin of surnames; altitudinal place of birth; and unsatisfied basic needs (UBN). The dataset was split into two groups, SGA and LGA, and compared with adequate for gestational age (AGA). Bivariate analysis (ANOVA) and general lineal modeling (GLM) with multinomial distribution were employed. Results: for SGA newborns, risk factors were altitude (1.43 [1.12–1.82]), preterm birth (5.33 [4.17–6.82]), older maternal age (1.59 [1.24–2.05]), and primiparous mothers (1.88 [1.06–3.34]). For LGA newborns, the risk factors were female sex (2.72 [5.51–2.95]), overweight (1.33 [1.22–2.46]) and obesity (1.85 [1.66–2.07]). Conclusions: the distribution of birth size and the factors related to its variability in Jujuy are found to be strongly conditioned by provincial terrain and the clinal variation due to its Andean location.

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STR Markers Unveil Microgeographic Differentiation over the Steep Mountainous Landscape of Jujuy Province, Northwest Argentina

Cited by 3 publications

References 39 publications

Paternal heritage in Jujuy province (Northwest Argentina): Evidence for sex‐biased gene flow and genetic drift effects

Paternal heritage in Jujuy province (Northwest Argentina): Evidence for sex‐biased gene flow and genetic drift effects

Newborn anthropometry, maternal capital, and altitude in the highland population from the province of Jujuy, Argentina

Birth Size and Maternal, Social, and Environmental Factors in the Province of Jujuy, Argentina

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