Strahlentherapie nichtmaligner Erkrankungen

Seegenschmiedt, M. Heinrich; Micke, Oliver

doi:10.1007/s00066-012-0195-z

Cited by 23 publications

(13 citation statements)

References 71 publications

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“…In addition, radiotherapy is known to be effective in a large variety of degenerative and hyperproliferative benign conditions [9]. In terms of hypersplenism due to splenic congestion the value of radiotherapy is limited to two case series as illustrated below [10,11].…”

Section: Discussionmentioning

confidence: 99%

Low-dose splenic irradiation in symptomatic congestive splenomegaly: report of five cases with literature data

2014

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BackgroundTo show effectiveness of low-dose splenic irradiation in symptomatic congestive splenomegaly.MethodsFive patients were referred to our department for symptomatic congestive splenomegaly within three years. Primary diseases were autoimmune hepatitis with liver cirrhosis (n = 2), cystic fibrosis (n = 1), granulomatous liver disease (n = 1) and Werlhof disease with liver cirrhosis (n = 1). Mean age was 54 years (range: 36–67). Patients received splenic irradiation with a total dose of 3 Gy (single dose: 0.5 Gy). One patient was re-irradiated after long-term failure with the same treatment schedule.ResultsIn four patients long term relief of splenic pain could be observed during the follow-up time of median 20 (range: 2–36) months. Four patients showed haematological response after irradiation with an increase of erythrocytes, leucocytes and/or platelets. A slightly decrease in spleen size was found in two patients.ConclusionsLow-dose splenic irradiation in symptomatic congestive splenomegaly is feasible and perhaps as effective as in lympho-and myeloproliferative malignancies regarding pain relief and haematological response.

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Section: Discussionmentioning

confidence: 99%

Low-dose splenic irradiation in symptomatic congestive splenomegaly: report of five cases with literature data

2014

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“…LD-RT not only influences cells of the innate immune system, but also modulates the function of endothelial cells (ECs) (Seegenschmiedt and Micke 2012). These cells are sensitive for a variety of stimuli like IR or inflammatory markers as well, and therefore a potential target in RT.…”

Section: Purposementioning

confidence: 99%

Immunomodulatory properties of low-dose ionizing radiation on human endothelial cells

Schröder

Juerß

Kriesen

et al. 2018

International Journal of Radiation Biology

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“…Against this background, a randomized study comparing no treatment versus either 21 or 30 Gy applied in 3-Gy single fractions over 2 weeks (7 Gy × 3 Gy) or by repeated 5 Gy × 3 Gy at intervals of 12 weeks has been conducted in patients with DD. After a median follow-up of 8 years, both regimes were significantly superior regarding disease progression and avoidance of preceding surgery compared to the control group (9). In a huge retrospective cohort, Betz et al further analyzed a total of 135 DD patients (208 hands) treated with a total dose of 30 Gy, in two intervals of 5 daily fractions of 3.0 Gy, separated by 6–8 weeks.…”

Section: Use Of Rt To Treat Benign Disordersmentioning

confidence: 86%

“…Non-malignant indications for LD-RT comprise about 10–30% of all patient cases treated in most academic, public, and private RT facilities in Germany (4, 9). In total, more than 50,000 patients per year are treated by LD-RT with the largest group suffering from painful degenerative musculoskeletal diseases, followed by symptomatic functional and hyperproliferative disorders with the latter to increase in numbers by 28.8% from 1999 to 2004 (8).…”

Section: Use Of Rt To Treat Benign Disordersmentioning

confidence: 99%

Basics of Radiation Biology When Treating Hyperproliferative Benign Diseases

et al. 2017

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For decades, low- and moderate-dose radiation therapy (RT) has been shown to exert a beneficial therapeutic effect in a multitude of non-malignant conditions including painful degenerative muscoloskeletal and hyperproliferative disorders. Dupuytren and Ledderhose diseases are benign fibroproliferative diseases of the hand/foot with fibrotic nodules and fascial cords, which determine debilitating contractures and deformities of fingers/toes, while keloids are exuberant scar formations following burn damage, surgery, and trauma. Although RT has become an established and effective option in the management of these diseases, experimental studies to illustrate cellular composites and factors involved remain to be elucidated. More recent findings, however, indicate the involvement of radiation-sensitive targets like mitotic fibroblasts/myofibroblasts as well as inflammatory cells. Radiation-related molecular mechanisms affecting these target cells include the production of free radicals to hamper proliferative activity and interference with growth factors and cytokines. Moreover, an impairment of activated immune cells involved in both myofibroblast proliferative and inflammatory processes may further contribute to the clinical effects. We here aim at briefly describing mechanisms contributing to a modulation of proliferative and inflammatory processes and to summarize current concepts of treating hyperproliferative diseases by low and moderate doses of ionizing radiation.

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Strahlentherapie nichtmaligner Erkrankungen

Cited by 23 publications

References 71 publications

Low-dose splenic irradiation in symptomatic congestive splenomegaly: report of five cases with literature data

Low-dose splenic irradiation in symptomatic congestive splenomegaly: report of five cases with literature data

Immunomodulatory properties of low-dose ionizing radiation on human endothelial cells

Basics of Radiation Biology When Treating Hyperproliferative Benign Diseases

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