Straightforward synthesis of biologically valuable nonsymmetrical malonamides under mild conditions

Abstract

Nonsymmetrical malonamides are often found in pharmacologically relevant molecules. A flexible and atom-economical method is developed for efficient preparation of nonsymmetrical malonamides from commercial or readily available isocyanates and β-ketoamides....

Photoinduced Direct Carbamoylation of Ethers with Isocyanates towards the Synthesis of α-Amide-Substituted Ether Derivatives

“…Owing to the special feature of the -N=C=O functional group similar to heterocumulene, a series of carbon-based nucleophilic addition reactions have been achieved. [37][38][39][40][41][42][43][44][45][46] Above all, isocyanates have been seen as a significant synthetic building block of amides which could be attacked by radical species and display good reactivity. In 2015, Kanai et al synthesized a series of tertiary carbamates from isocyanates without prefunctionalization or installation of a directing group.…”