Straightforward synthesis of diverse dipyrazolylmethane derivatives and their application for fluorescence sensing of Cu²⁺ ions

Abstract

Various dipyrazolylmethanes were synthesized and nitro-substituted compound displayed an excellent turn-off fluorescence sensing property for the detection of Cu2+ ions.

Trifluoromethyl‐β‐dicarbonyls as Versatile Synthons in Synthesis of Heterocycles

“…Kaliraj et al described a concise and practical one-pot approach for synthesis of highly functionalized dipyrazolylmethane derivatives 169 involving reaction of arylhydrazine hydrochlorides 54 with ethyl 4,4-di/trifluoro-3-oxobutanoate 1 (X=H, F) and DMF as carbon source and solvent in presence of p-TsOH as Bronsted acid catalyst (Scheme 50). [135] However, the reaction in the absence of Bronsted acid or using other Bronsted acid such as pyridium hydrochloride, trifluoroacetic acid or AcOH afforded desired product ). [136] Authors employed pyridinium chlorochromate (PCC), CAN, H 2 O 2 , MnO 2 and IBX as oxidant for oxidative aromatization of pyrazolines but the best results were obtained with IBX.…”

Synthesis and Evaluation of Thiomethyl-Substituted (4Z)-4-[(Pyrazol-4-yl)methylene]pyrazolone as an Optical Chemosensor

“…These heterocycles have also been used to synthesize probes for the detection of various chemical compounds, biomolecules, and several metallic ions [15]. For example, several dipyrazolylmethane derivatives were synthesized from 3-methyl-1-phenyl-2-pyrazolin-5one and used as fluorescent probes for the detection of Cu 2+ ions [16].…”