Strain, age, but not gender, influence ulcer severity induced by water-restraint stress

Paré, William P.

doi:10.1016/0031-9384(89)90083-8

Cited by 40 publications

(12 citation statements)

References 15 publications

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“…For example, this phenotype is characterized by elevated adrenocorticotropin (ACTH) in response to stress and resistance to glucocorticoid feedback (Redei et al, 1994;Rittenhouse et al, 2002). Additionally, WKY rats are more prone to develop restraint-induced ulcer (Pare and Schimmel, 1986;Pare, 1989b), suggesting that autonomic responses to stress are elevated, in addition to endocrine responses. Finally, in a number of behavioral procedures, WKY rats show a propensity toward passive coping behavior (Pare, 1992a(Pare, , 1993(Pare, , 1994.…”

Section: Introductionmentioning

confidence: 99%

Identifying Genes in Monoamine Nuclei that may Determine Stress Vulnerability and Depressive Behavior in Wistar–Kyoto Rats

Pearson

Stephen

Beck

et al. 2006

Neuropsychopharmacol

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The Wistar-Kyoto (WKY) rat is stress sensitive and exhibits depressive-like behavior. The locus coeruleus (LC)-norepinephrine and dorsal raphe (DR)-serotonin systems mediate certain aspects of the stress response and have been implicated in depression. Microarray technology was used to identify gene expression differences in the LC and DR between WKY vs Sprague-Dawley (SD) rats that might account for the WKY phenotype. RNA was isolated from microdissected LC and DR, amplified, and hybridized to microarrays (1 array/ subject, n ¼ 4/group). Significance of microarray (SAM) analysis revealed increased expression of 66 genes in the LC and 19 genes in the DR and decreased expression of 33 genes in the DR of WKY rats. Hierarchical clustering identified differences in gene expression profiles of WKY vs SD rats that generally concurred with SAM. Notably, genes that encoded for enzymes involved in norepinephrine turnover, amino-acid receptors, and certain G-protein-coupled receptors were elevated in the LC of WKY rats. The DR of WKY rats showed decreased expression of genes encoding several potassium channels and neurofilament genes. The chromosomal locations of 15 genes that were differentially expressed in WKY rats were near loci identified as contributing to depressive-like behaviors in the rat. The specific genes revealed by the present analysis as being differentially expressed in WKY rats may contribute to their unique behavioral profile and suggest targets that confer susceptibility to stress-related psychiatric disorders.

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Section: Introductionmentioning

confidence: 99%

Identifying Genes in Monoamine Nuclei that may Determine Stress Vulnerability and Depressive Behavior in Wistar–Kyoto Rats

Pearson

Stephen

Beck

et al. 2006

Neuropsychopharmacol

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“…The SIECm exhibited gastroprotective activity in this model. The activity of the extract on the model is a very important criterion to assess the extract's potential efficacy as an anti-ulcer prototype due to its pathophysiological similarity to human gastric ulcer (Paré, 1989).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the safety, gastroprotective activity and mechanism of action of standardised leaves infusion extract of Copaifera malmei Harms

Adzu

Balogun

Pavan

et al. 2015

Journal of Ethnopharmacology

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“…Information pertaining to threat evaluation is transmitted from the basolateral amygdala (BLA) to PL cortex through a direct projection that changes its directional plasticity in response to stress (Maroun and Richter-Levin, 2003; Maroun, 2006). Those studies were conducted in SD rats, which are not as stress sensitive as WKY rats (Pare, 1989; Tejani-Butt et al, 1994; Bravo et al, 2011; Jiao et al, 2011). Therefore, it is entirely possible that these regions of the WKY mPFC are not functioning in the same manner as the male SD rats during avoidance learning.…”

Section: Discussionmentioning

confidence: 99%

“…Others have documented strain (Powell, 1972; Sutterer et al, 1981; Berger and Starzec, 1988; Overstreet et al, 1990; Escorihuela et al, 1995; Blizard and Adams, 2002; Brush, 2003; Servatius et al, 2008) and sex (Beatty and Beatty, 1970; Gray and Lalljee, 1974; Archer, 1975; Van Oyen et al, 1981; Steenbergen et al, 1990; Heinsbroek et al, 1991; Díaz-Véliz et al, 2000; Beck et al, 2010) differences in avoidance susceptibility; however, WKY rats are a unique rodent, in that, they exhibit qualities of behavioral inhibition (low exploration of novel spaces and stimuli), but they also exhibit rapid acquisition of active-avoidance behavior, which they become resistant to extinguishing (Pare, 1989, 1994a,b, 2000; Servatius et al, 2008; McAuley et al, 2009; Beck et al, 2011; Jiao et al, 2011). This paradoxical combination of behaviorally inhibited temperament and facilitated avoidance acquisition could be due to an added sensitivity to stimuli that predict safety, not just those that predict threat.…”

Section: Introductionmentioning

confidence: 99%

ITI-Signals and Prelimbic Cortex Facilitate Avoidance Acquisition and Reduce Avoidance Latencies, Respectively, in Male WKY Rats

Beck

Jiao

Smith

et al. 2014

Front. Behav. Neurosci.

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As a model of anxiety disorder vulnerability, male Wistar-Kyoto (WKY) rats acquire lever-press avoidance behavior more readily than outbred Sprague-Dawley rats, and their acquisition is enhanced by the presence of a discrete signal presented during the inter-trial intervals (ITIs), suggesting that it is perceived as a safety signal. A series of experiments were conducted to determine if this is the case. Additional experiments investigated if the avoidance facilitation relies upon processing through medial prefrontal cortex (mPFC). The results suggest that the ITI-signal facilitates acquisition during the early stages of the avoidance acquisition process, when the rats are initially acquiring escape behavior and then transitioning to avoidance behavior. Post-avoidance introduction of the visual ITI-signal into other associative learning tasks failed to confirm that the visual stimulus had acquired the properties of a conditioned inhibitor. Shortening the signal from the entirety of the 3 min ITI to only the first 5 s of the 3 min ITI slowed acquisition during the first four sessions, suggesting the flashing light (FL) is not functioning as a feedback signal. The prelimbic (PL) cortex showed greater activation during the period of training when the transition from escape responding to avoidance responding occurs. Only combined PL + infralimbic cortex lesions modestly slowed avoidance acquisition, but PL-cortex lesions slowed avoidance response latencies. Thus, the FL ITI-signal is not likely perceived as a safety signal nor is it serving as a feedback signal. The functional role of the PL-cortex appears to be to increase the drive toward responding to the threat of the warning signal. Hence, avoidance susceptibility displayed by male WKY rats may be driven, in part, both by external stimuli (ITI signal) as well as by enhanced threat recognition to the warning signal via the PL cortex.

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Strain, age, but not gender, influence ulcer severity induced by water-restraint stress

Cited by 40 publications

References 15 publications

Identifying Genes in Monoamine Nuclei that may Determine Stress Vulnerability and Depressive Behavior in Wistar–Kyoto Rats

Identifying Genes in Monoamine Nuclei that may Determine Stress Vulnerability and Depressive Behavior in Wistar–Kyoto Rats

Evaluation of the safety, gastroprotective activity and mechanism of action of standardised leaves infusion extract of Copaifera malmei Harms

ITI-Signals and Prelimbic Cortex Facilitate Avoidance Acquisition and Reduce Avoidance Latencies, Respectively, in Male WKY Rats

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