Strain and sex differences in brain and behaviour of adult rats: Learning and memory, anxiety and volumetric estimates

Keeley, Robin J.; Bye, Cameron M.; Trow, Jan E.; McDonald, Robert J.

doi:10.1016/j.bbr.2014.10.039

Cited by 59 publications

(27 citation statements)

References 92 publications

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“…Sex differences in freezing during CS+ and CS− presentation were analyzed separately in the different groups of rats that underwent one, two or three days of discrimination training using two-way analysis of variance (ANOVA), with sex and CS type as between- and within-subject factors, respectively. Direct comparisons between freezing during CS+ and CS− presentation in males and females that underwent one, two or three days of discrimination training were also conducted separately using independent paired t -tests (Keeley et al, 2015, Lynch et al, 2013). Contextual fear was inferred from freezing during the 2 min period before tone presentations, which was scored as above.…”

Section: Methodsmentioning

confidence: 99%

Sex differences in discriminating between cues predicting threat and safety

Day

Reed

Stevenson

2016

Neurobiology of Learning and Memory

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Section: Methodsmentioning

confidence: 99%

Sex differences in discriminating between cues predicting threat and safety

Day

Reed

Stevenson

2016

Neurobiology of Learning and Memory

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“…All handling and injection treatments began following the determination of puberty onset, as discussed in a companion paper [46]. All handling and injection treatments took place in the last 4 h of the rat's dark cycle, which is their active phase.…”

Section: Puberty Onset and Drug Administrationmentioning

confidence: 99%

Part II: Strain- and sex-specific effects of adolescent exposure to THC on adult brain and behaviour: Variants of learning, anxiety and volumetric estimates

Keeley

Trow

Bye

et al. 2015

Behavioural Brain Research

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“…Deficits in learning performance across spatial and contextual learning tasks in the Wistar lineage have previously been reported, which suggests that they do not form context parings in an easy and efficient pathway (Keeley et al, 2015). However, the comparison of specific results between Wistar and SD rats are, in some cases, conflicting; this difference may be explained by the differences in the behavioral task.…”

Section: Discussionmentioning

confidence: 99%

A Window on the Study of Aversive Instrumental Learning: Strains, Performance, Neuroendocrine, and Immunologic Systems

Oliveira

Gouveia

Castro

et al. 2016

Front. Behav. Neurosci.

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The avoidance response is present in pathological anxiety and interferes with normal daily functions. The aim of this article is to shed light on performance markers of active avoidance (AA) using two different rat strains, Sprague-Dawley (SD) and Wistar. Specifically, good and poor performers were evaluated regarding anxiety traits exhibited in the elevated plus maze (EPM) and corticosterone levels and motor activity in the open field test. In addition, the plasma levels of Interleukin-6 (IL-6), Interleukin-1Beta (IL-1beta), Nerve Growth Factor Beta (NGF-beta), Tumor Necrosis Factor-Alpha (TNF-alpha) and cytokine-induced neutrophil chemoattractant 1 (CINC-1) were compared in the good and poor performers to better understand the role of the immunologic system in aversive learning. Behavioral criteria were employed to identify subpopulations of SD and Wistar rats based on their behavioral scores during a two-way AA test. The animals were tested for anxiety-like behavior in the EPM and motor activity in the open-field test. Plasma corticosterone levels were measured at the end of the avoidance test. Cytokine levels of IL-6, IL-1beta, NGF-beta, TNF-alpha, and CINC-1 were measured in the plasma of the Wistar rats. Sixty-six percent of the Wistar rats and 35% of the SD rats exhibited a poor performance. This feature was associated with a decrease in anxiety-like behavior in the EPM. The poor and good performers exhibited lower levels of corticosterone compared with the control animals, which suggests that training alters corticosterone levels, thereby leading to hypocortisolism, independent of the performance. The CINC-1 levels were increased in the poor performers, which reinforces the role of immunologic system activation in learning deficits. Our study provides a better understanding of the complex interactions that underlie neuroimmune consequences and their implications for performance.

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Strain and sex differences in brain and behaviour of adult rats: Learning and memory, anxiety and volumetric estimates

Cited by 59 publications

References 92 publications

Sex differences in discriminating between cues predicting threat and safety

Sex differences in discriminating between cues predicting threat and safety

Part II: Strain- and sex-specific effects of adolescent exposure to THC on adult brain and behaviour: Variants of learning, anxiety and volumetric estimates

A Window on the Study of Aversive Instrumental Learning: Strains, Performance, Neuroendocrine, and Immunologic Systems

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