Strain by virtual extensometers and video-imaging optical coherence tomography as a repeatable metric for IOP-Induced optic nerve head deformations

Mapping Pulsatile Optic Nerve Head Deformation Using OCT

“…Recent studies in primates 17 and mice 16 also used the concept of analyzing consecutive B-scans to measure deformation after artificially induced high IOP changes. They show bigger lamina cribrosa displacements with higher intraocular pressure.…”

“…Recent studies in rodents 16 and non-human primates 17 have exploited video-OCT to probe the biomechanics of the ONH, but until now this has not been achieved in human subjects. Indeed, human in vivo characterization of pulseinduced optic nerve head deformation could provide valuable information to evaluate the biomechanical properties of the glaucomatous optic nerve.…”

Optical coherence elastography and its applications for the biomechanical characterization of tissues

“…(A) Diagram of the compressional OCE system. (B) En‐face optical coherence tomography (OCT) image; (C) The qualitative elastogram; (D) The quantitative elastogram; A, adipose; FC, ductal carcinoma with focal calcification; N, ductal carcinoma with necrosis; S, stroma [27].…”

“…The elasticity of human tissues (such as the iris, corneal, retina, skin, breast, arteries, etc.) has been measured by various OCE methods [25][26][27][28][29][30], which are meaningful for monitoring and understanding the development of the diseases.…”

“…Optical coherence elastography applications for elasticity assessment of human tissues, including the iris [25], the cornea [26], the retina [27], the skin [28], the breast [29], and the artery [30]. …”