Strain comparisons in inhibitory discrimination learning and novel object recognition procedures

Waite, Linda J.; Bonardi, Charlotte; Stevenson, Carl W.; Cassaday, Helen J.

doi:10.1016/j.physbeh.2021.113557

Cited by 5 publications

(4 citation statements)

References 36 publications

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“…This ratio was statistically significantly (p < 0.05) increased by 98.6% after DPG was administered to cadmium-intoxicated rats, reflecting recognition memory improvement. Of note, the obtained values for the discrimination ratio in control rats are in agreement with previously published studies [40][41][42][43][44][45]. In addition to the discrimination ratio, we measured the total exploration time (Figure 2B) and the mean object exploration time (for the old and novel objects; Figure 2C).…”

Section: Dapagliflozin Rescued Recognition Memory Deterioration In Ca...supporting

confidence: 90%

Targeting Autophagy, Apoptosis, and Oxidative Perturbations with Dapagliflozin Mitigates Cadmium-Induced Cognitive Dysfunction in Rats

Arab,

Eid,

Alsufyani

et al. 2023

Biomedicines

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Cognitive decline and Alzheimer-like neuropathology are common manifestations of cadmium toxicity. Thanks to its antioxidant/anti-apoptotic features, dapagliflozin has demonstrated promising neuroprotective actions. However, its effect on cadmium-induced neurotoxicity is lacking. The present work aimed to examine whether dapagliflozin could protect rats from cadmium-evoked cognitive decline. In this study, the behavioral disturbances and hippocampal biomolecular alterations were studied after receiving dapagliflozin. Herein, cadmium-induced memory/learning decline was rescued in the Morris water maze, novel object recognition task, and Y-shaped maze by dapagliflozin. Meanwhile, the hippocampal histopathological abnormalities were mitigated. The molecular mechanisms revealed that dapagliflozin lowered hippocampal expression of p-tau and Aβ42 neurotoxic proteins while augmenting acetylcholine. The cognitive enhancement was triggered by hippocampal autophagy stimulation, as indicated by decreased SQSTM-1/p62 and Beclin 1 upregulation. Meanwhile, a decrease in p-mTOR/total mTOR and an increase in p-AMPK/total AMPK ratio were observed in response to dapagliflozin, reflecting AMPK/mTOR cascade stimulation. Dapagliflozin, on the other hand, dampened the pro-apoptotic processes in the hippocampus by downregulating Bax, upregulating Bcl-2, and inactivating GSK-3β. The hippocampal oxidative insult was mitigated by dapagliflozin as seen by lipid peroxide lowering, antioxidants augmentation, and SIRT1/Nrf2/HO-1 pathway activation. In conclusion, dapagliflozin’s promising neuroprotection was triggered by its pro-autophagic, anti-apoptotic, and antioxidant properties.

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Section: Dapagliflozin Rescued Recognition Memory Deterioration In Ca...supporting

confidence: 90%

Targeting Autophagy, Apoptosis, and Oxidative Perturbations with Dapagliflozin Mitigates Cadmium-Induced Cognitive Dysfunction in Rats

Arab,

Eid,

Alsufyani

et al. 2023

Biomedicines

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“…Despite the overwhelming similarities in the developmental trajectories of the three rat strains in our study, there are some small differences, with the most usual being in the amount of exploration different strains exhibited in sample or/and test phase. This could reflect known differences in vision between albino and pigmented rat strains ( Andrews et al, 1995 ; Prusky et al, 2002 ; Kumar et al, 2015 ; Waite et al, 2021 ). Despite the differences in object exploration between rat strains, our correlation analyses did not reveal any consistent relationships.…”

Section: Discussionmentioning

confidence: 99%

Developmental trajectory of episodic-like memory in rats

Asiminas

Lyon

Langston

et al. 2022

Front. Behav. Neurosci.

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IntroductionEpisodic memory formation requires the binding of multiple associations to a coherent episodic representation, with rich detail of times, places, and contextual information. During postnatal development, the ability to recall episodic memories emerges later than other types of memory such as object recognition. However, the precise developmental trajectory of episodic memory, from weaning to adulthood has not yet been established in rats. Spontaneous object exploration tasks do not require training, and allow repeated testing of subjects, provided novel objects are used on each trial. Therefore, these tasks are ideally suited for the study of the ontogeny of episodic memory and its constituents (e.g., object, spatial, and contextual memory).MethodsIn the present study, we used four spontaneous short-term object exploration tasks over two days: object (OR), object-context (OCR), object-place (OPR), and object-place-context (OPCR) recognition to characterise the ontogeny of episodic-like memory and its components in three commonly used outbred rat strains (Lister Hooded, Long Evans Hooded, and Sprague Dawley).ResultsIn longitudinal studies starting at 3–4 weeks of age, we observed that short term memory for objects was already present at the earliest time point we tested, indicating that it is established before the end of the third week of life (consistent with several other reports). Object-context memory developed during the fifth week of life, while both object-in-place and the episodic-like object-place-context memory developed around the seventh postnatal week. To control for the effects of previous experience in the development of associative memory, we confirmed these developmental trajectories using a cross-sectional protocol.DiscussionOur work provides robust evidence for different developmental trajectories of recognition memory in rats depending on the content and/or complexity of the associations and emphasises the utility of spontaneous object exploration tasks to assess the ontogeny of memory systems with high temporal resolution.

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“…However, Renard et al ( 46) also found that saline-treated LH but not Wistar rats were able to recognize a novel object after a 120 min inter-trial interval. In contrast, a more recent study showed that both Wistar and LH rats performed well in the NOR test even after a 24 h inter-trial interval (49). To fully understand the role of eCB and strain interactions on behavior, more studies using both albino and pigmented strains are needed.…”

Section: Urb Does Not a Ect Recognition Memory In Lister Hooded Ratsmentioning

confidence: 93%

URB597 induces subtle changes to aggression in adult Lister Hooded rats

et al. 2022

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The endocannabinoid system has been implicated in both social and cognitive processing. The endocannabinoid metabolism inhibitor, URB597, dose-dependently improves non-social memory in adult Wistar and Sprague Dawley rats, whereas its effect on social interaction (SI) is affected by both rat strain and drug dose. Lister Hooded rats consistently respond differently to drug treatment in general compared with albino strains. This study sought to investigate the effects of different doses of URB597 on social and non-social memory in Lister Hooded rats, as well as analyzing the behavioral composition of the SI. Males were tested for novel object recognition (NOR), social preference (between an object and an unfamiliar rat), social novelty recognition (for a familiar vs. unfamiliar rat) and SI with an unfamiliar rat. URB597 (0.1 or 0.3 mg/kg) or vehicle was given 30 min before testing. During SI testing, total interaction time was assessed along with time spent on aggressive and explorative behaviors. Lister Hooded rats displayed expected non-social and social memory and social preference, which was not affected by URB597. During SI, URB597 did not affect total interaction time. However, the high dose increased aggression, compared to vehicle, and decreased anogenital sniffing, compared to the low dose of URB597. In summary, URB597 did not affect NOR, social preference or social recognition memory but did have subtle behavioral effects during SI in Lister hooded rats. Based on our findings we argue for the importance of considering strain as well as the detailed composition of behavior when investigating drug effects on social behavior.

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Strain comparisons in inhibitory discrimination learning and novel object recognition procedures

Cited by 5 publications

References 36 publications

Targeting Autophagy, Apoptosis, and Oxidative Perturbations with Dapagliflozin Mitigates Cadmium-Induced Cognitive Dysfunction in Rats

Targeting Autophagy, Apoptosis, and Oxidative Perturbations with Dapagliflozin Mitigates Cadmium-Induced Cognitive Dysfunction in Rats

Developmental trajectory of episodic-like memory in rats

URB597 induces subtle changes to aggression in adult Lister Hooded rats

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