The assessment of the fatigue life of critical, highly stressed component areas is an important aspect in the design of thick-walled components for wind turbines made of nodular cast iron. With the demand for resource efficiency through lightweight design combined with a certain capability to withstand extreme loads and special events, this issue is becoming increasingly important. However, there are still gaps in the description of local strain-based material behaviour. For the design and local strain-based fatigue assessment of large cast components, possibilities to determine the fatigue life as accurately as possible must be provided by standards and guidelines. The paper aims to provide a wide range of material and fatigue data from one common source for general design interests. During research projects at Fraunhofer LBF, material properties for the PRAM-based fatigue life assessment and the elastic-plastic material behaviour have been derived from 9 nodular cast iron grades with 44 microstructural variations. To describe the influence of the technological size effect on cyclic stress-strain and PRAM-N curves the quasi-static parameters (tensile strength and elongation at break) and the microstructure (nodularity and graphite particle density) are considered. In addition, suggestions for scatter bands in the strain-based design approach are given to the designers of thick-walled GJS components.