2014
DOI: 10.1016/j.reprotox.2014.10.018
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Strain-dependent effects of transforming growth factor-β1 and 2 during mouse secondary palate development

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Cited by 8 publications
(5 citation statements)
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“…Here, we found that TGFB2 is a possible target gene of miR-193a-3p. TGFB2 belongs to the transforming growth factor beta family, which regulates a wide variety of biological phenomena, such as cellular development, morphology, proliferation, apoptosis, and epithelial-mesenchymal transition (EMT), and has been considered to play an important role in the morphogenesis of the palate (Iordanskaia and Nawshad, 2011;Jin and Ding, 2014). Knockout of TGFB2 in mice results in perinatal mortality and a wide range of developmental defects, including cardiac, lung, craniofacial, and limb defects (Azhar et al, 2009).…”
Section: Discussionmentioning
confidence: 99%
“…Here, we found that TGFB2 is a possible target gene of miR-193a-3p. TGFB2 belongs to the transforming growth factor beta family, which regulates a wide variety of biological phenomena, such as cellular development, morphology, proliferation, apoptosis, and epithelial-mesenchymal transition (EMT), and has been considered to play an important role in the morphogenesis of the palate (Iordanskaia and Nawshad, 2011;Jin and Ding, 2014). Knockout of TGFB2 in mice results in perinatal mortality and a wide range of developmental defects, including cardiac, lung, craniofacial, and limb defects (Azhar et al, 2009).…”
Section: Discussionmentioning
confidence: 99%
“…Wnt-mediated Tgfβ3 activation is required for MEE cell apoptosis during palatal shelf closure (He et al, 2011) (Fig. 2), and knockout of all three isoforms of Tgfβ has been associated with cleft palate in mice, in either single or doubly mutant lines (Kaartinen et al, 1995; Sanford et al, 1997; Jin and Ding, 2014) (Fig. 2).…”
Section: Wnt Signaling Crosstalk With Other Morphogenetic Signaling Pmentioning
confidence: 99%
“…Since then, the effect of strain background on knock-out mice has been supported by numerous studies and has become the consensus of the field [ 10 ]. The effect of strain background on gene function during mouse secondary palate development has also been described recently [ 11 ]. The mechanisms underlying the strain effects are not yet well understood.…”
Section: Introductionmentioning
confidence: 99%