Strain-dependent sex differences in the effects of alcohol on cocaine-induced taste aversions

Jones, Jermaine D.; Busse, Gregory D.; Riley, Anthony L.

doi:10.1016/j.pbb.2006.03.017

Cited by 24 publications

(19 citation statements)

References 69 publications

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“…Finally, another commonly used model is based on the conditioned preference or avoidance of a place that has been associated with an addictive substance (Randall- Thompson and Riley, 2003;Busse et al, 2005;Jones et al, 2006;Rinker et al, 2008). In the conditioned place preference paradigm, with the use of cocaine, female rats exhibit place preference in fewer trials than male rats (Russo et al, 2003a,b).…”

Section: Sex Differences In Animal Models Of Substance-related Disordersmentioning

confidence: 99%

“…However, it has been found that the response rate is highest during oestrus and this is not due to enhanced activity levels (Prescott, 1966). Also, peak ICSS response with stimulation of the pars compacta of the substantia nigra has been observed in the night of prooestrous to oestrus (Steiner et al, 1981).Finally, another commonly used model is based on the conditioned preference or avoidance of a place that has been associated with an addictive substance (Randall-Thompson and Riley, 2003;Busse et al, 2005;Jones et al, 2006;Rinker et al, 2008). In the conditioned place preference paradigm, with the use of cocaine, female rats exhibit place preference in fewer trials than male rats (Russo et al, 2003a,b).…”

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Sex differences in animal models of psychiatric disorders

Kokras

Dalla

2014

British J Pharmacology

359

187

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Psychiatric disorders are characterized by sex differences in their prevalence, symptomatology and treatment response. Animal models have been widely employed for the investigation of the neurobiology of such disorders and the discovery of new treatments. However, mostly male animals have been used in preclinical pharmacological studies. In this review, we highlight the need for the inclusion of both male and female animals in experimental studies aiming at gender-oriented prevention, diagnosis and treatment of psychiatric disorders. We present behavioural findings on sex differences from animal models of depression, anxiety, post-traumatic stress disorder, substance-related disorders, obsessive-compulsive disorder, schizophrenia, bipolar disorder and autism. Moreover, when available, we include studies conducted across different stages of the oestrous cycle. By inspection of the relevant literature, it is obvious that robust sex differences exist in models of all psychiatric disorders. However, many times results are conflicting, and no clear conclusion regarding the direction of sex differences and the effect of the oestrous cycle is drawn. Moreover, there is a lack of considerable amount of studies using psychiatric drugs in both male and female animals, in order to evaluate the differential response between the two sexes. Notably, while in most cases animal models successfully mimic drug response in both sexes, test parameters and treatment-sensitive behavioural indices are not always the same for male and female rodents. Thus, there is an increasing need to validate animal models for both sexes and use standard procedures across different laboratories. LINKED ARTICLESThis article is part of a themed section on Animal Models in Psychiatry Research. To view the other articles in this section visit http://dx.doi.org/10. 1111/bph.2014.171.issue-20 Abbreviations 5-HTT, 5-HT transporter; 8-OH-DPAT, 7-(Dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol; Akt1, V-akt murine thymoma viral oncogene homologue 1; BDNF, brain-derived neurotrophic factor; BTBR, BTBR T + tf/J; CMS, chronic mild stress; COMT, catechol-O-methyltransferase-deficient mice; CR, conditioned response; CRF, corticotrophinreleasing factor; CS, conditioned stimulus; D1 receptor, dopamine 1 receptor; D2 receptor, dopamine 2 receptor; DISC1, disrupted-in-schizophrenia 1; Ehmt1, euchromatin histone methyltransferase 1; FBGRKO, forebrain glucocorticoid type II receptor (NR3C1) knockout; FSL, flinders sensitive rat line; FST, forced swim test; GSK3, glycogen synthase kinase 3; HAB, high anxiety-related behaviour rats; ICSS, intracranial self-stimulation; LAB, low anxiety-related behaviour rats; LI, latent inhibition; Mthfr, methylenetetrahydrofolate reductase; OCD, obsessive-compulsive disorder; PPI, prepulse inhibition; PTSD, post-traumatic stress disorder; SSRI, selective 5-HT re-uptake inhibitors; US, unconditioned stimulus; WKY, Wistar Kyoto IntroductionThe total disease burden for neuropsychiatric disorders in the European Union has been recently ...

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Section: Sex Differences In Animal Models Of Substance-related Disordersmentioning

confidence: 99%

mentioning

confidence: 99%

Sex differences in animal models of psychiatric disorders

Kokras

Dalla

2014

British J Pharmacology

359

187

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“…One factor that has received considerable attention is the sex of the subject used in the FAL procedure. Sex differences in FAL have been examined with a variety of compounds such as lithium chloride (LiCl) (Chambers et al, 1981;Dacanay et al, 1984), cocaine (Busse et al, 2005;Jones et al, 2006) and ethanol (Caihol and Mormede, 2002;Morales et al, 2014;Schramm-Sapyta et al, 2014;Sherrill et al, 2011a). The relative sensitivity of males (compared to females) within this preparation is generally reported, although the strength of the sex difference varies across studies and is dependent upon a number of factors (see Busse et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Sex differences in adult Wistar rats in the voluntary consumption of ethanol after pre-exposure to ethanol-induced flavor avoidance learning

Torre

Escarabajal

Zapata

2015

Pharmacology Biochemistry and Behavior

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“…The choice for extending this analysis to mice is twofold. First, species (and strain) differences have been reported in aversion learning and the effects of various manipulations on such learning (Caihol and Mormede, 2002; Jones et al, 2006). As such, it is unknown to what degree the work with rats generalizes to other rodent species.…”

Section: Introductionmentioning

confidence: 99%

Differential involvement of the norepinephrine, serotonin and dopamine reuptake transporter proteins in cocaine-induced taste aversion

Jones

Hall

Uhl

et al. 2009

Pharmacology Biochemistry and Behavior

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Despite the impact of cocaine's aversive effects on its abuse potential, the neurochemical basis of these aversive effects remains poorly understood. By blocking the reuptake of the monoamine neurotransmitters dopamine (DA), norepinephrine (NE) and serotonin (5-HT) into the presynaptic terminal, cocaine acts as a potent indirect agonist of each of these systems. The following studies attempted to assess the extent of monoaminergic mediation of cocaine's aversive effects using conditioned taste aversion (CTA) learning (Garcia, 1955). Specifically, Experiment 1 assessed the ability of selective monoamine transporter inhibitors, e.g., DAT (vanoxerine), NET (nisoxetine) and SERT (fluoxetine), to induce taste aversions (relative to cocaine). Only the NET inhibitor approximated the aversive strength of cocaine. Experiment 2 compared the effects of pretreatment of each of these transport inhibitors on the development of a cocaine-induced CTA. Pretreatment with nisoxetine and fluoxetine both attenuated cocaine-induced aversions in a manner comparable to that produced by cocaine itself. The DAT inhibitor was without effect. Combined, the results of these investigations indicate little or no involvement of dopaminergic systems in cocaine's aversive effects while NE appears to contribute most substantially, with a possible modulatory involvement by serotonin.

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Strain-dependent sex differences in the effects of alcohol on cocaine-induced taste aversions

Cited by 24 publications

References 69 publications

Sex differences in animal models of psychiatric disorders

Sex differences in animal models of psychiatric disorders

Sex differences in adult Wistar rats in the voluntary consumption of ethanol after pre-exposure to ethanol-induced flavor avoidance learning

Differential involvement of the norepinephrine, serotonin and dopamine reuptake transporter proteins in cocaine-induced taste aversion

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