Strain Differences During Intraventricular Infusion of Norepinephrine: Possible Role of Receptor Sensitivity

Segal, David S.; Geyer, Mark A.; Weiner, Brian C.

doi:10.1126/science.1145205

Cited by 62 publications

(12 citation statements)

References 27 publications

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“…However, both rats of the latter strain and animals treated with PNMT inhibitors also show an equal upregulation of the density of brainstem a 1 -adrenoceptors (presumably postsynaptic to the source of EPI) and, in addition, an enhanced motor response to ivt. catecholamine injection (Segal et al, 1975), suggesting that brain a 1 -as well as a 2 -adrenoceptors are innervated by EPI. This agrees with the finding that EPI has the highest efficacy of all tested catecholamines at a 1 -receptors coupled to phosphatidylinositol hydrolysis or potentiation of cAMP responses in rat brain slices (Johnson and Minneman, 1986).…”

Section: Epi As An Endogenous Neurotransmitter At a 1 -Receptorsmentioning

confidence: 98%

Emerging Evidence for a Central Epinephrine-Innervated α1-Adrenergic System that Regulates Behavioral Activation and is Impaired in Depression

Stone

Yang

Rosengarten

et al. 2003

Neuropsychopharmacol

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Currently, most basic and clinical research on depression is focused on either central serotonergic, noradrenergic, or dopaminergic neurotransmission as affected by various etiological and predisposing factors. Recent evidence suggests that there is another system that consists of a subset of brain a 1B -adrenoceptors innervated primarily by brain epinephrine (EPI) that potentially modulates the above three monoamine systems in parallel and plays a critical role in depression. The present review covers the evidence for this system and includes findings that brain a 1 -adrenoceptors are instrumental in behavioral activation, are located near the major monoamine cell groups or target areas, receive EPI as their neurotransmitter, are impaired or inhibited in depressed patients or after stress in animal models, and are restored by a number of antidepressants. This 'EPI-a 1 system' may therefore represent a new target system for this disorder.

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Section: Epi As An Endogenous Neurotransmitter At a 1 -Receptorsmentioning

confidence: 98%

Emerging Evidence for a Central Epinephrine-Innervated α1-Adrenergic System that Regulates Behavioral Activation and is Impaired in Depression

Stone

Yang

Rosengarten

et al. 2003

Neuropsychopharmacol

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“…Some studies report large strain differences, which under controlled environmental conditions, could be due to genetic differences. Rat strains have also been found to be differentially sensitive to amphetamines (Camp et al, 1994;Miserendino et al, 2003;Segal et al, 1975), and one study found that the strain distribution patterns for sensitivity to the locomotor stimulant effects of cocaine and d-amphetamine were not identical (George et al, 1991). However, even for two of the most commonly used inbred mouse strains (or sometimes their sublines), C57BL/6 and DBA/2, the strain sensitivity order for amphetamine locomotor response has not been consistent (Anisman et al, 1975;Cabib et al, 2000;Orsini et al, 2004;Phillips et al, 1994;Remington and Anisman, 1976;Wenger, 1989;Zocchi et al, 1998).…”

Section: Inbred Strain Studiesmentioning

confidence: 99%

Behavioral genetic contributions to the study of addiction-related amphetamine effects

Phillips

Kamens

Wheeler

2008

Neuroscience & Biobehavioral Reviews

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Amphetamines, including methamphetamine, pose a significant cost to society due to significant numbers of amphetamine-abusing individuals who suffer major health-related consequences. In addition, methamphetamine use is associated with heightened rates of violent and property-related crimes. The current paper reviews the existing literature addressing genetic differences in mice that impact behavioral responses thought to be relevant to the abuse of amphetamine and amphetaminelike drugs. Summarized are studies that used inbred strains, selected lines, single gene knockouts and transgenics, and quantitative trait locus (QTL) mapping populations. Acute sensitivity, neuroadaptive responses, rewarding and conditioned effects are among those reviewed. Some gene mapping work has been accomplished, and although no amphetamine-related complex trait genes have been definitively identified, translational work leading from results in the mouse to studies performed in humans is beginning to emerge. The majority of genetic investigations has utilized single-gene knockout mice and has concentrated on dopamine-and glutamate-related genes. Genes that code for cell support and signaling molecules are also well-represented. There is a large behavioral genetic literature on responsiveness to amphetamines, but a considerably smaller literature focused on genes that influence the development and acceleration of amphetamine use, withdrawal, relapse, and behavioral toxicity. Also missing are genetic investigations into the effects of amphetamines on social behaviors. This information might help to identify at-risk individuals and in the future to develop treatments that take advantage of individualized genetic information.

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“…As pioneered by the Segal laboratory and others, animal models of locomotor behavior have been critical tools for understanding the relationships between monoamines and behavior (Geyer and Segal, 1991;Kelly and Iversen, 1976;Lat, 1965;Schiorring, 1979;Segal et al, 1975Segal et al, , 1971Segal and Mandell, 1970;Stinus et al, 1980). Such behavioral models have provided a foundation for much of what we know regarding the neural correlates of behavioral effects of drugs of abuse, in particular psychotomimetics such as stimulants and hallucinogens (Adams and Geyer, 1982;Bankson and Cunningham, 2001;Creese, 1983;Eilam et al, 1989;Fink and Morgenstern, 1985;Geyer, 1990;Lehmann-Masten and Geyer, 1991;Segal, 1975;Segal et al, 1981Segal et al, , 1980Swerdlow and Koob, 1985).…”

Section: Introductionmentioning

confidence: 99%

Differential Contributions of Dopamine D1, D2, and D3 Receptors to MDMA-Induced Effects on Locomotor Behavior Patterns in Mice

Risbrough

Masten

Caldwell

et al. 2006

Neuropsychopharmacol

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MDMA or 'ecstasy' (3,4-methylenedioxymethamphetamine) is a commonly used psychoactive drug that has unusual and distinctive behavioral effects in both humans and animals. In rodents, MDMA administration produces a unique locomotor activity pattern, with high activity characterized by smooth locomotor paths and perseverative thigmotaxis. Although considerable evidence supports a major role for serotonin release in MDMA-induced locomotor activity, dopamine (DA) receptor antagonists have recently been shown to attenuate these effects. Here, we tested the hypothesis that DA D 1 , D 2 , and D 3 receptors contribute to MDMA-induced alterations in locomotor activity and motor patterns. DA D 1 , D 2 , or D 3 receptor knockout (KO) and wild-type (WT) mice received vehicle or ( + /À)-MDMA and were tested for 60 min in the behavioral pattern monitor (BPM). D 1 KO mice exhibited significant increases in MDMA-induced hyperactivity in the late testing phase as well as an overall increase in straight path movements. In contrast, D 2 KO mice exhibited reductions in MDMA-induced hyperactivity in the late testing phase, and exhibited significantly less sensitivity to MDMA-induced perseverative thigmotaxis. At baseline, D 2 KO mice also exhibited reduced activity and more circumscribed movements compared to WT mice. Female D 3 KO mice showed a slight reduction in MDMA-induced hyperactivity. These results confirm differential modulatory roles for D 1 and D 2 and perhaps D 3 receptors in MDMA-induced hyperactivity. More specifically, D 1 receptor activation appears to modify the type of activity (linear vs circumscribed), whereas D 2 receptor activation appears to contribute to the repetitive circling behavior produced by MDMA.

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Strain Differences During Intraventricular Infusion of Norepinephrine: Possible Role of Receptor Sensitivity

Cited by 62 publications

References 27 publications

Emerging Evidence for a Central Epinephrine-Innervated α1-Adrenergic System that Regulates Behavioral Activation and is Impaired in Depression

Emerging Evidence for a Central Epinephrine-Innervated α1-Adrenergic System that Regulates Behavioral Activation and is Impaired in Depression

Behavioral genetic contributions to the study of addiction-related amphetamine effects

Differential Contributions of Dopamine D1, D2, and D3 Receptors to MDMA-Induced Effects on Locomotor Behavior Patterns in Mice

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