Strain differences in the anxiolytic effects of losartan in the mouse

Gard, Paul R.; Haigh, Samantha J; Cambursano, Piero T; Warrington, Claire

doi:10.1016/s0091-3057(01)00491-9

Cited by 30 publications

(27 citation statements)

References 20 publications

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“…Comparative analysis of the different mice strains helps us to understand their characteristics and potential uses (Crawley et al 1997;Gard et al 2001;Lucki et al 2001;Voikar et al 2001;Kim et al 2002;Bothe et al 2005;Brooks et al 2005). One factor limiting the widespread experimental use of Sabra mice is the lack of sufficient data concerning the features of this strain.…”

Section: Discussionmentioning

confidence: 99%

Comparative Analysis of the Behavioral and Biomolecular Parameters of Four Mouse Strains

et al. 2011

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The use of mice as experimental models in pharmacological and biochemical research began over 100 years ago, during which time different mice strains with specific features were developed. Numerous studies demonstrate that the pharmacological efficacy of various compounds significantly varies among different animal strains, a factor which must be considered when analyzing experimental data. The Sabra strain, developed more than 35 years ago, is widely used for research in Israel but has an unclear origin and is not characterized as well as other strains. Comparative analyses of the molecular characteristics of Sabra and other strains should help to understand their characteristics and to enhance the validity of their experimental use. Thus, four mouse strains-outbred ICR and Sabra as well as inbred C57Bl/6J and Balb/c were compared. Animals' weight, blood corticosterone and hippocampal BDNF mRNA levels were measured, and animals' behavior was compared using the EPM, open field, FST, and hot plate tests. We found that although Sabra mice are bigger and heavier than other tested lines, this is not reflected in behavior or in biomolecular features, wherein Sabra mice lay within the diapason of other tested animals. Thus, behavioral tests of anxiety-like behavior and locomotor activity revealed that Sabra mice scored close to the mean of all tested lines. Analysis of blood corticosterone levels did not show significant differences among tested strains. We also found a correlation between general and locomotor activity of the tested strains and their hippocampal BDNF mRNA expression. In summary, we may conclude that Sabra mice have traits similar to the better known lines, and therefore they are good subjects for neuroscience research.

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Section: Discussionmentioning

confidence: 99%

Comparative Analysis of the Behavioral and Biomolecular Parameters of Four Mouse Strains

et al. 2011

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“…In particular, the brain ACE, ANG II, and AT 1 receptor has been reported to have an important role in cardiovascular regulation under stress condition (2). Evidence in humans and animals show that ACE inhibitors can modulate anxiety and behavior (26,27,42). Pretreatment with the AT 1 antagonist, candesartan, deeply modifies the response to stressors, preventing sympathetically mediated effects and the production of gastric ulcerations (52).…”

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confidence: 99%

Activation of angiotensin-converting enzyme 2/angiotensin-(1–7)/Mas axis attenuates the cardiac reactivity to acute emotional stress

Lima

Xavier

Ferreira

et al. 2013

American Journal of Physiology-Heart and Circulatory Physiology

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Recent data indicate the brain angiotensin-converting enzyme/ANG II/AT1 receptor axis enhances emotional stress responses. In this study, we investigated whether its counterregulatory axis, the angiotensin-converting enzyme 2 (ACE2)/ANG-(1-7)/Mas axis, attenuate the cardiovascular responses to acute emotional stress. In conscious male Wistar rats, the tachycardia induced by acute stress (air jet 10 l/min) was attenuated by intravenous injection of ANG-(1-7) [Δ heart rate (HR): saline 136 ± 22 vs. ANG-(1-7) 61 ± 25 beats/min; P < 0.05]. Peripheral injection of the ACE2 activator compound, XNT, abolished the tachycardia induced by acute stress. We found a similar effect after intracerebroventricular injections of either ANG-(1-7) or XNT. Under urethane anesthesia, the tachycardia evoked by the beta-adrenergic agonist was markedly reduced by ANG-(1-7) [ΔHR: saline 100 ± 16 vs. ANG-(1-7) 18 ± 15 beats/min; P < 0.05]. The increase in renal sympathetic nerve activity (RSNA) evoked by isoproterenol was also abolished after the treatment with ANG-(1-7) [ΔRSNA: saline 39% vs. ANG-(1-7) -23%; P < 0.05]. The tachycardia evoked by disinhibition of dorsomedial hypothalamus neurons, a key nucleus for the cardiovascular response to emotional stress, was reduced by ∼45% after intravenous injection of ANG-(1-7). In cardiomyocyte, the incubation with ANG-(1-7) (1 μM) markedly attenuated the increases in beating rate induced by isoproterenol. Our data show that activation of the ACE2/ANG-(1-7)/Mas axis attenuates stress-induced tachycardia. This effect might be either via the central nervous system reducing anxiety level and/or interfering with the positive chronotropy mediated by activation of cardiac β adrenergic receptors. Therefore, ANG-(1-7) might contribute to reduce the sympathetic load to the heart during situations of emotional stress, reducing the cardiovascular risk.

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“…These differences could be explained by different ways of administration, the strain of animal used, or the time of testing after drug administration [4,31]. In this way, if we analyze the time-dependent response, it was previously demonstrated using open-field behavior, that angiotensin II initially increases anxiety-like behavior (e.g.…”

Section: Discussionmentioning

confidence: 99%

Effects of angiotensin II receptor antagonists on anxiety and some oxidative stress markers in rat

Ciobîcă

Bild²,

Hrițcu

et al. 2011

Open Medicine

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AbstractIn addition to its known classical roles, the renin angiotensin system (RAS) has more subtle functions which include the regulation of emotional responses. Previous studies regarding the anxiety related behavior of RAS have showed controversial results. There is also evidence that oxidative stress accompanies angiotensin II infusion, but the role of AT1/AT2 specific receptors is not clear. The aim of this study was to evaluate the effects of central angiotensin II receptor blockers on anxiety state and oxidative stress. Behavioral testing included elevated plus maze, while oxidative stress status was measured though the extent of a lipid peroxidation product (malondialdehyde-MDA) and the specific activity of some defense antioxidant enzymes (superoxide dismutase-SOD and glutathione peroxidase-GPx). The rats treated with angiotensin II spent significantly less time in the open-arms of elevated-plus-maze, while the administration of losartan resulted in a significant increase of this time. We observed a significant increase of MDA concentration in the angiotensin II group and a decrease of MDA levels in both losartan and PD-123177 groups. In addition, a significant correlation was seen between the time spent in the open arms and oxidative stress markers. These findings could lead to important therapeutic aspects regarding the use of angiotensin II receptor blockers in anxiety-related disorders.

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Strain differences in the anxiolytic effects of losartan in the mouse

Cited by 30 publications

References 20 publications

Comparative Analysis of the Behavioral and Biomolecular Parameters of Four Mouse Strains

Comparative Analysis of the Behavioral and Biomolecular Parameters of Four Mouse Strains

Activation of angiotensin-converting enzyme 2/angiotensin-(1–7)/Mas axis attenuates the cardiac reactivity to acute emotional stress

Effects of angiotensin II receptor antagonists on anxiety and some oxidative stress markers in rat

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