Strain differences in the development of auto-anti-idiotypic antibody regulation with age: Genetic linkage to the Igh-C locus

Age-Related Strain Differences in the Development of Auto-Anti-Idiotypic Antibody Regulation in the Splenic and Mucosal-Associated Lymphoid Systems

“…The solid bar represents the geometric mean of the individual data points. Parts of the splenic data are front previously published observations [27] and arc presented here to facilitate comparison. experimental animal group and.…”

“…The t test was used to evaluate the statistical significance of natural log-transformed data from aged animals as compared with data from the 2-month-old group. Parts of these data are from previously pub lished observations [27] and are presented here to facilitate comparison. sponse to TNP-BGG.…”

“…This PFC-inhibitory activity of immune sera correlated well with anti-[anti-TNP F(ab')2 IgG] titers deter mined by passive hemagglutination. Parts of these titer data are from previously published observations [27] and are presented here to facilitate comparison.…”

“…In con trast, C57BL/6J, DBA/J, and C3H/HeJ mice produced a significantly higher percentage of hapten-augmentable PFC at 8-9 months of age, as compared with values from the 2-month-old group. Parts of these data (splenic PFC levels) are from previously published observations [27] and are presented here to facilitate comparison.…”

“…We have previously shown that the ap pearance, with age, of anti-idiotype-blocked, hapten-augmentable PFC in the spleen, after immunization with trinitrophenyl bovine gamma globulin (TNP-BGG), is a straindependent phenomenon [27], In the present study, we investigated the effect of aging on the development of anti-idiotype-blocked. hapten-augmentable PFC in the mucosalassociated LN of various strains of mice and compared these effects with those changes occurring in the spleen.…”