Strain Variation of Respiratory Syncytial Virus

Morgan, L.; Routledge, E. G.; Willcocks, M. M.; Samson, A. C. R.; Scott, R.; Toms, G. L.

doi:10.1099/0022-1317-68-11-2781

Cited by 53 publications

(42 citation statements)

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“…A wide predominance of HRSV group A strain circulation was observed during the 17 consecutive periods analyzed, in agreement with most of the previous reports. In some countries where both groups co-circulated, group A was always predominant (Storch & Park 1987, Morgan et al 1987, Carballal et al 2000.…”

Section: Circulation Of Antigenic Groups a And Bmentioning

confidence: 99%

Molecular epidemiology of human respiratory syncytial virus in Uruguay: 1985-2001 - A review

Arbiza

Delfraro

Frabasile

2005

Mem. Inst. Oswaldo Cruz

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Section: Circulation Of Antigenic Groups a And Bmentioning

confidence: 99%

Molecular epidemiology of human respiratory syncytial virus in Uruguay: 1985-2001 - A review

Arbiza

Delfraro

Frabasile

2005

Mem. Inst. Oswaldo Cruz

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“…reactions with monoclonal and polyclonal antibodies (Coates et al, 1966;Anderson et al, 1985;Mufson et al, 1985Mufson et al, , 1987Gimenez et al, 1986;Hendry et al, 1986;Akerlind & Norrby, 1986;Johnson et al, 1987a;Morgan et al, 1987;Orvell et al, 1987). Information on the extent of naturally occurring antigenic and structural diversity among RSV strains is important for guiding vaccine development and might also provide additional insight into the structure, function and evolution of RSV vRNA and its gene products.…”

mentioning

confidence: 99%

The 1B (NS2), 1C (NS1) and N Proteins of Human Respiratory Syncytial Virus (RSV) of Antigenic Subgroups A and B: Sequence Conservation and Divergence within RSV Genomic RNA

Johnson

Collins

1989

Journal of General Virology

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SUMMARYA 2330 nucleotide sequence spanning tlae 1B (NS2), IC (NS1) and N genes and intergenic regions of human respiratory syncytial virus strain 18537, representing antigenic subgroup B, was determined by sequencing cloned cDNAs of intracellular mRNAs. Comparison with the previously reported sequences for strain A2 of subgroup A showed that 1B, 1C and N were highly conserved at the nucleotide level (78, 78 and 86~ identity, respectively) and at the amino acid level (92, 87 and 96~o identity, respectively). The gene-start signals were exactly conserved between subgroups, and the gene-end signals contained only a single nucleotide substitution each in 1B and N. In most cases intergenic and non-coding gene sequences that were not part of presumed transcriptive signals were much less well conserved (generally 50 to 71~) than sequences that were part of translational open reading frames (82 to 86~). The nucleotide and deduced amino acid sequences of the N gene and protein of the Long strain of subgroup A were determined by sequencing cDNA clones of intracellular mRNA; the nucleotide sequence (representing all but the first 10 nucleotides of the gene) contained 15 differences from that of the A2 strain, but the deduced amino acid sequences were identical.

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“…The greatest differences were observed within glycoprotein G. Antigenic groups are in correlation with different genotypes (Mufson et al, 1985;Cristina et al, 1990;Go�schalk et al, 1996). A greater number of the examined viruses showed that they are not homogeneous within the one group (Morgan et al, 1987;Orvell et al, 1987;Cristina et al, 1990). Greater variability was generally found in viruses of the antigenic group A (Venter et al, 2001).…”

Section: Antigenic Variabilitymentioning

confidence: 89%

“…Similar results were previously detected in human respiratory viruses too, when it seemed that viruses of a given antigenic group are homogenous. Increased amounts of data on different strains of the virus made us believe that antigenic and structural differences exist within individual groups (Morgan et al, 1987;Orvell et al, 1987;Storch et al, 1991). The above-mentioned impossibility to classify some BRSV viruses into antigenic groups and two reactivity pa�erns of B group viruses with G-specific monoclonal antibodies suggest that similar antigenic differences also exist in BRS viruses.…”

Section: Antigenic Variabilitymentioning

confidence: 99%

“…The differences in reactivity with the given monoclonal antibodies (mAbs) and in nucleotide sequences are expressed at certain levels in some proteins: the a�achment proteins G, F and SH, nucleoprotein N and protein P (Morgan et al, 1987;Orvell et al, 1987;Cristina et al, 1990). The greatest differences were observed within glycoprotein G. Antigenic groups are in correlation with different genotypes (Mufson et al, 1985;Cristina et al, 1990;Go�schalk et al, 1996).…”

Section: Antigenic Variabilitymentioning

confidence: 99%

See 1 more Smart Citation

The antigenic and genetic variability of bovine respiratory syncytial virus with emphasis on the G protein

Valentová¹

2003

Vet. Med.

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Bovine respiratory syncytial virus (BRSV) and related human respiratory syncytial virus (HRSV) are major respiratory tract pathogens in calves and infants, respectively. Great attention is now paid to prevention of the disease caused by these agents. Glycoprotein G is the most variable viral protein and antigenic grouping of RSV isolates is based on distinct antigenic reactivity patterns determined with a set of G protein specific mAbs. Genetic variability of the G protein is used during epidemiology and epizootiology studies of HRSV and BRSV diseases, respectively. The constant genetic drift can be observed within G protein sequences. Both cell-mediated and antibody-mediated immune responses contribute to efficient protection against RSV infection. The neutralizing antibodies are induced by F and G proteins. The G protein fails to induce cytotoxic lymphocytes response and may causes aberrant Th2 response leading to enhancement of clinical symptoms in subsequently infected vaccines. The G as the most variable viral protein associated with immunopathologic effect is a critical factor in vaccine development.

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Strain Variation of Respiratory Syncytial Virus

Cited by 53 publications

References 0 publications

Molecular epidemiology of human respiratory syncytial virus in Uruguay: 1985-2001 - A review

Molecular epidemiology of human respiratory syncytial virus in Uruguay: 1985-2001 - A review

The 1B (NS2), 1C (NS1) and N Proteins of Human Respiratory Syncytial Virus (RSV) of Antigenic Subgroups A and B: Sequence Conservation and Divergence within RSV Genomic RNA

The antigenic and genetic variability of bovine respiratory syncytial virus with emphasis on the G protein

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