Strategic Approaches to in Vitro Neurotoxicology

Campbell, Iain C.; Abdulla, Elizabeth McFarlane

doi:10.1016/b978-012168055-8/50036-4

Cited by 10 publications

(6 citation statements)

References 82 publications

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“…(Shivprasad HN et al, 2005) Free radicals are involved in the development of degenerative diseases. (Campbell I C et al,1995) They have also been implicated in the pathogenesis of diabetes, liver damage, nephrotoxicity, inflammation, cancer, cardiovascular disorders, neurological disorders, and in the process of aging. (Marx J L 1987) To protect these free radical induced damage, antioxidants are the most popular agents that interactively and synergistically neutralize free radicals.…”

Section: Introductionmentioning

confidence: 99%

In-Vitro Antioxidant Activity of Ethanolic Extract of Centaurea behen

Chougule¹,

Pawar²,

Limaye³

et al. 2012

J. App. Pharm. Sci

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The present investigation was conducted to investigate the in-vitro activity of ethanolic extract of Roots of Centaurea behens by using DPPH radical scavenging activity, nitric oxide radical scavenging activity, hydrogen peroxide radical scavenging activity, hydroxyl radical. Result suggests that the extract possess significant antioxidant activity as compared to the standard ascorbic acid and thus further in vivo investigation is required to evaluate the medicinal significance of the extract which can be used for assessing the possible therapeutic importance of the drug.

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Section: Introductionmentioning

confidence: 99%

In-Vitro Antioxidant Activity of Ethanolic Extract of Centaurea behen

Chougule¹,

Pawar²,

Limaye³

et al. 2012

J. App. Pharm. Sci

View full text Add to dashboard Cite

show abstract

“…These types of species are involved in activation of many types of procarcinogens and promutagens. Free radicals react with biomolecules like DNA, RNA, lipid, and protein and result in gene mutation and cell structure damage and lead to development of cancer, cardiovascular disorder, neurodegenerative disease (Alzheimer's disease, Parkinson's disease), atherosclerosis, liver injury, diabetes mellitus [3,4]. Reactive oxygen species (ROS) exerts oxidative stress towards the cells of human to face 10000 oxidative hit per second and when this type of hit breaks antioxidant defense mechanism, the free radicals then attack cell macromolecules and lead to a number of physiological disorders [4].…”

Section: Introductionmentioning

confidence: 99%

DPPH Scavenging Assay of Eighty Four Bangladeshi Medicinal Plants

Uddin¹

2013

IOSR-JPBS

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This study was designed to screen out free radical scavenging potentiality of 84 medicinal plants.Stock solution of different plant extracts and standard were diluted to achieve suitable concentrations. A control was also prepared without plant extract solution. Then 0.004% DPPH solution was added. The mixtures were incubated in the room temperature for 30 minutes. Then the absorbance was measured at 517 nm against solvent in UV-spectrophotometer and then IC50 was calculated. In this experiment two standard were usedascorbic acid and BHT. Both showed a significant IC50 value of 15.5µg/mL, and 46.54µg/mL respectively. Among 84 medicinal plants Syzygim cumini, Casuarina littorea, Borassus flabellifer, Enhydra fluctuans, and Minusops elengi exhibited highest radical scavenging potential with an IC50 value of 12.816µg/mL, 14.467µg/mL, 15.755µg/mL, 15.653µg/mL, and 20.380µg/mL respectively. All these value are very close to the IC50 value of ascorbic acid and better than IC50 value of BHT (Butylated Hydroxy Toluene). Syzygim cumini is the most powerful scavenger among all tested medicinal plants and also most strong scavenger than ascorbic acid and BHT. Scavenging activity was found to increase in dose dependent manner. Another 30 medicinal plants exhibited good scavenging property and 14 medicinal plants showed moderate scavenging activity. The rest presented lower scavenging activity. This present study indicates that plants having good scavenging property may have various health beneficial effects and these plants can be considered as valuable source of bioactive components with high antioxidant properties.

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“…Free radicals induce damage or death of that cell of which the affected molecule is a part. The propagation of free radical formation could continue for thousands of reactions and hence the damage caused will be extensive (Campbell and Abdulla, 1995). Lipids, proteins and DNA are all susceptible to attack by free radicals.…”

Section: Cyanide Intoxication and Antioxidants/oxidants Balancementioning

confidence: 99%

Modification by Aqueous Extracts of Allium kurrat L. and Ricinus communis L. of Cyanide Nephrotoxicity on Balb/C Mice

Elsaid¹

2012

Oxidative Stress - Environmental Induction and Dietary Antioxidants

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Strategic Approaches to in Vitro Neurotoxicology

Cited by 10 publications

References 82 publications

In-Vitro Antioxidant Activity of Ethanolic Extract of Centaurea behen

In-Vitro Antioxidant Activity of Ethanolic Extract of Centaurea behen

DPPH Scavenging Assay of Eighty Four Bangladeshi Medicinal Plants

Modification by Aqueous Extracts of Allium kurrat L. and Ricinus communis L. of Cyanide Nephrotoxicity on Balb/C Mice

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