The least developed and developing countries need to increase their energy consumption to support economic growth. However, such growth in energy demand could potentially result in a substantial increase in greenhouse gas emissions. Herein lies one of the biggest challenges of the 21st century: providing energy that enables economic growth in the least developed and developing regions while meeting climate stabilization goals. Macro energy system modeling efforts can yield critical insights that inform climate and energy policy in the least developed and developing regions. They can inform research and development priorities, financing needs, and international negotiations. Now is the time for governments, non-profits, and research institutions to support the macro energy system modeling community in the least developed and developing countries.