Utilization in learning with a hybrid concept certainly cannot be separated from the use of e-learning, especially during the Covid-19 pandemic that began in 2020. E-Learning is a must-have for a university in adapting the learning carried out by lecturers to students. Students and other academic processes such as teaching, assigning assignments and filling in student score data. This study aims to see the effectiveness of the use of E-Learning (SISFO) to improve the performance and academic learning of a lecturer. The research was conducted in 2022 using a mixed method (Qualitative and Quantitative). The research sample was taken using random sampling technique and obtained as many as 26 Lecturers of the University of PGRI Palembang. Data was collected by means of questionnaires, literature studies, and interviews. The data that has been collected is then analyzed descriptive quantitative. The results showed that the average score of the lecturer performance indicators was in the very high category, namely 4.4 with a percentage of 88%. While in the academic learning of lecturers, the average score of academic learning indicators is 4.36 with a percentage of 87.23 in the very high category. SISFO PGRI University Palembang also has 16 features of learning activities and 7 features of learning resources that facilitate lecturers in implementing e-learning. These results indicate that the use of E-learning SISFO used at PGRI Palembang University supports lecturer performance and academic learning takes place effectively.