Strategic Outlook toward 2030: Japan's research for allergy and immunology – Secondary publication

Adachi, Takeya; Kainuma, Keigo; Asano, Koichiro; Amagai, Masayuki; Arai, Hiroyuki; Ishii, Ken J.; Ito, Komei; Uchio, Eiichi; Ebisawa, Motohiro; Okano, Mitsuhiro; Kabashima, Kenji; Kondo, Kenji; Konno, Satoshi; Saeki, Hidehisa; Sonobe, Mariko; Nagao, Mizuho; Hizawa, Nobuyuki; Fukushima, Atsuki; Fujieda, Shigeharu; Matsumoto, Kenji; Morita, Hideaki; Yamamoto, Kazuhiko; Yoshimoto, Akemi; Tamari, Mayumi

doi:10.1016/j.alit.2020.04.006

Cited by 14 publications

(10 citation statements)

References 38 publications

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“…For Japan, a society ageing at a globally unprecedented pace, a comprehensive and cross‐sectional study of adult‐onset allergic and immunological diseases is quite indispensable. Therefore, the Strategic Outlook towards 2030: Japan's Research for Allergy and Immunology, established by a multi‐disciplinary committee comprising the Ministry of Health, Labour and Welfare of Japan, clinical and basic researchers, patients, and public groups, has proposed that the promotion of research and development for adult‐onset eosinophilic airway diseases is as important as that of childhood‐onset allergic diseases 7 . In this review, we will discuss the pathophysiology, genetics and clinical features of late‐onset eosinophilic asthma, N‐ERD, ABPA/ABPM, EGPA and CRSwNP/eosinophilic CRS.…”

Section: Introductionmentioning

confidence: 99%

Adult‐onset eosinophilic airway diseases

Asano

Ueki

Tamari

et al. 2020

Allergy

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Allergic diseases in the upper and the lower airways such as allergic rhinitis and atopic asthma are usually accompanied by local eosinophilia and sometimes by peripheral blood eosinophilia. Chronic rhinosinusitis with nasal polyps (CRSwNP) and nonatopic asthma are also characterized by local and systemic eosinophilia; however, there are substantial differences in the age of onset and the presence of atopy. Atopic asthma and allergic rhinitis develop during childhood in most cases and mediated by type 1 hypersensitivity reactions to allergen(s), as are other childhood-onset allergic diseases such as food allergies and eczema. Patients often develop these diseases consecutively as an allergic march (Figure 1), suggesting the presence of common genetic backgrounds and pathophysiology. In contrast to childhood-onset disease, adult-onset asthma frequently presents as a nonatopic and eosinophilic condition, 1-6

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Section: Introductionmentioning

confidence: 99%

Adult‐onset eosinophilic airway diseases

Asano

Ueki

Tamari

et al. 2020

Allergy

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“…In conclusion, we conducted impact analyses from multiple perspectives, including indicators related to substantiality 2 and index words profiling/clustering based on the national strategy. 3 These findings may inform international collaborative long‐term research that strategically leverages each research funding institution's strengths.…”

Section: Tablementioning

confidence: 98%

“…To determine the kind of indicators needed for the funding strategy, we compared the research impact of funding agencies (FAs) in the UK, US, and Japan, utilizing indices related to research substantiality 2 and analyzing index words/abstracts connected with the national strategy for allergy and immunology. 3 …”

Section: Tablementioning

confidence: 99%

“…Further, we analyzed MeSH headings for relevance to national unique Strategic Outlook toward 2030 formulated by the Ministry of Health, Labour and Welfare of Japan (Figure 1F , Table S1 ). 3 While most projects were pathogenic studies, AMED‐PPAI funded research published more papers on precision medicine and host‐extrinsic factor relations (Action I‐2, I‐3). The Action II and III groups were not strongly represented.…”

Section: Tablementioning

confidence: 99%

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Research impact analysis of international funding agencies in the realm of allergy and immunology

Adachi

Ogawa

Fukushi

et al. 2022

Allergy

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To the Editor, A longitudinal approach should be employed for research and development (R&D) on allergic and immunological diseases across all life stages. To strategically use limited public funds in promoting such R&D, their characteristics of long-term research support and societal implementation should be considered. 1 However, outcomes of the funding research evaluation have focused on conventional, shortsighted indicators. To determine the kind of indicators needed for the funding strategy, we compared the research impact of funding agencies (FAs) in the UK, US, and Japan, utilizing indices related to research substantiality 2 and analyzing index words/abstracts connected with the national strategy for allergy and immunology. 3 We used AMEDfind-an open database of top-down R&D projects funded by AMED-and selected 53 awards for a Practical Research Project for Allergic Diseases and Immunology (AMED-PPAI) (Figure S1). 1053 papers with verified PubMed IDs were included. As the controls, we selected the Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section (NIH-HAI), an immunology-focused project in the Americas, and Human Immunology Unit (MRC-HIU), that in Europe, extracting 373 US papers and 118 UK papers, published in 2015-2019, respectively (see Appendix S1 for all methods).The Field-Weighted Citation Impact (FWCI)-evaluating research paper quality-was highest for MRC-HIU following NIH-HAI and AMED-PPAI (Table 1, Figure 1A). Although the international co-authorship rate was lowest in the AMED-PPAI, the annual trend showed a gradual increase (Figure 1B, Table 1). The number of top 10% most cited papers 2 /value, evaluating funding efficiency, was highest for MRC-HIU (Table 1).To characterize these outputs, we performed natural language analyses of the top 50 FWCI papers from three FAs and top 100 papers on this topic during 2015-2019 (Figure 1C-E). 4 Although all FAs produced mainly basic allergy/immunology study papers (e.g., clusters 0, 1, 2, and 9 in Figure 1D), AMED-PPAI produced relativelyThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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“…The disease appears to evolve, changing its presentation with varying onsets, levels of severity, and responses to treatment based on the individual [3,4]. Therefore, a deeper understanding of the underlying pathophysiology and establishing an effective strategy to comprehensively assess changing symptoms become imperative to provide tailored, longitudinal care and to improve patients' quality of life [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Reliability and Validity of Electronic Patient-Reported Outcomes Using the Smartphone App AllerSearch for Hay Fever: Prospective Observational Study

Akasaki¹,

Inomata²,

Sung³

et al. 2022

JMIR Form Res

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Background Hay fever is a highly prevalent, heterogenous, and multifactorial disease. Patients may benefit from longitudinal assessments using mobile health (mHealth) principles. We have previously attempted to establish an effective mHealth platform for patients with hay fever through AllerSearch, our in-house smartphone app that assesses electronic patient-reported outcomes through a questionnaire on hay fever and provides evidence-based advice. To be used by the public, an investigation on its reliability and validity is necessary. Objective The aim of this paper is to assess the reliability and validity of subjective symptom data on hay fever collected through our app, AllerSearch. Methods This study used a prospective observational design. The participants were patients aged ≥20 years recruited from a single university hospital between June 2, 2021, and January 26, 2022. We excluded patients who could not use smartphones as well as those with incomplete data records and outlier data. All participants answered the Japanese Allergic Conjunctival Disease Standard Quality of Life Questionnaire (JACQLQ), first in the paper-and-pencil format and subsequently on AllerSearch on the same day. The JACQLQ comprises the following three domains: Domain I, with 9 items on ocular or nasal symptoms; Domain II, with 17 items on daily activity and psychological well-being; and Domain III, with 3 items on overall condition by face score. The concordance rate of each domain between the 2 platforms was calculated. The internal consistency of Domains I and II of the 2 platforms was assessed using Cronbach alpha coefficients, the concurrent validity of Domains I and II was assessed by calculating Pearson correlation coefficients, and the mean differences between the 2 platforms were assessed using Bland-Altman analysis. Results In total, 22 participants were recruited; the data of 20 (91%) participants were analyzed. The average age was 65.4 (SD 12.8) years, and 80% (16/20) of the participants were women. The concordance rate of Domains I, II, and III between the paper-based and app-based JACQLQ was 0.78, 0.85, and 0.90, respectively. The internal consistency of Domains I and II between the 2 platforms was satisfactory (Cronbach alpha of .964 and .919, respectively). Pearson correlation analysis yielded a significant positive correlation between Domains I and II across the 2 platforms (r=0.920 and r=0.968, respectively). The mean difference in Domains I and II between the 2 platforms was 3.35 units (95% limits of agreement: –6.51 to 13.2). Conclusions Our findings indicate that AllerSearch is a valid and reliable tool for the collection of electronic patient-reported outcomes to assess hay fever, contributing to the advantages of the mHealth platform.

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Strategic Outlook toward 2030: Japan's research for allergy and immunology – Secondary publication

Cited by 14 publications

References 38 publications

Adult‐onset eosinophilic airway diseases

Adult‐onset eosinophilic airway diseases

Research impact analysis of international funding agencies in the realm of allergy and immunology

Reliability and Validity of Electronic Patient-Reported Outcomes Using the Smartphone App AllerSearch for Hay Fever: Prospective Observational Study

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