The establishment of national experimental teaching demonstration centers (NETDCs) in China has played an important role in improving the experimental teaching level in universities and colleges, promoting scientific research, and cultivating innovative talents for national- and region-level innovations. However, how to promote the sustainable development of NETDCs in China is becoming a critical issue. This paper constructs a new theoretical model for evaluating the sustainable development of NETDCs in China. This model consists of 5 dimensions (i.e., environmental, structural, human, teaching, and output entropies), 11 primary indicators, and 34 secondary indicators. A multidimensional scale for evaluating the sustainable development of NETDCs was developed and validated based on 24,483 questionnaires from 895 NETDCs in China. The results show that the development level and overall level of NETDCs in China for all 11 primary indicators are uneven. Policy measures for promoting the sustainable development of NETDCs are proposed and discussed.