As numerous travel information is provided on digital platforms, information literacy is becoming increasingly important for tourists to address travel-related problems and ensure a smooth tour experience. This study conceptualizes e-tourism information literacy (eTIL) based on previous researches and develops a scale to measure this construct following a systematic approach, from which, 14 items were generated to measure four underlying dimensions of eTIL: information knowledge, information skills, information awareness, and information ethics. Additionally, to examine the interplay between eTIL, information quality, and system quality, fuzzy-set qualitative comparative analysis (fsQCA) is employed on 399 samples to obtain equifinal configurations that lead to tourist satisfaction with online travel information (TSOTI). The results revealed two configurations leading to high TSOTI and three configurations leading to low TSOTI. This study contributes theoretically by constructing the concept of eTIL and explaining its role in driving TSOTI.