Strategic use of nanotechnology in drug targeting and its consequences on human health: A focused review

Maurya, Anand Kumar; Singh, Anurag; Mishra, Gaurav; Kumari, K Meena; Rai, Anshul; Sharma, Bhupesh; Kulkarni, Giriraj T.; Awasthi, Rajendra

doi:10.1556/1646.11.2019.04

Cited by 28 publications

(18 citation statements)

References 187 publications

(193 reference statements)

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“…The great importance that is given to these nanocarriers is due to their good stability and the ability to encapsulate a high amount of substances. A recent report has indicated that many biodegradable and non-biodegradable polymeric nanocarriers can be applied for oral drug delivery [115]. The successful study of curcumin-loaded polymeric NPs provided 5.6-fold higher oral bioavailability compared with pure curcumin.…”

Section: In Vitro and Vivo Toxicological Studiesmentioning

confidence: 99%

“…The successful study of curcumin-loaded polymeric NPs provided 5.6-fold higher oral bioavailability compared with pure curcumin. Similar to curcumin, in vivo study of silymarin from orally administered polymeric nanoemulsion has proved 4-fold higher efficiency than conventional silymarin suspension [115]. Natural polymers, such as chitosan, dextran, heparin, or hyaluronan have been widely used for drug delivery studies having their biodegradable, biocompatible and mucoadhesive properties [114].…”

Section: In Vitro and Vivo Toxicological Studiesmentioning

confidence: 99%

“…Biocompatibility, biodegradability and non-toxicity are the main characteristics of polymeric NPs [ 111 , 113 , 114 ]. According to Maurya et al (2019) [ 115 ], polymeric NPs are safe for human use and they can improve the bioavailability of the loaded drugs. The great importance that is given to these nanocarriers is due to their good stability and the ability to encapsulate a high amount of substances.…”

Section: In Vitro and Vivo Toxicological Studiesmentioning

confidence: 99%

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Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology

et al. 2020

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Polymeric nanoparticles (NPs) are particles within the size range from 1 to 1000 nm and can be loaded with active compounds entrapped within or surface-adsorbed onto the polymeric core. The term “nanoparticle” stands for both nanocapsules and nanospheres, which are distinguished by the morphological structure. Polymeric NPs have shown great potential for targeted delivery of drugs for the treatment of several diseases. In this review, we discuss the most commonly used methods for the production and characterization of polymeric NPs, the association efficiency of the active compound to the polymeric core, and the in vitro release mechanisms. As the safety of nanoparticles is a high priority, we also discuss the toxicology and ecotoxicology of nanoparticles to humans and to the environment.

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Section: In Vitro and Vivo Toxicological Studiesmentioning

confidence: 99%

Section: In Vitro and Vivo Toxicological Studiesmentioning

confidence: 99%

Section: In Vitro and Vivo Toxicological Studiesmentioning

confidence: 99%

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Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology

et al. 2020

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“…The nanotechnology that was initiated in 1960s has generated a variety of nanomaterials valuable for biomedical applications such as cancer therapy [ 1 ]. Of particular interest are nanoparticles—small particles of the size ranging from 40 to 400 nm [ 2 , 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Studies on the Exposure of Gadolinium Containing Nanoparticles with Monochromatic X-rays Drive Advances in Radiation Therapy

et al. 2020

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While conventional radiation therapy uses white X-rays that consist of a mixture of X-ray waves with various energy levels, a monochromatic X-ray (monoenergetic X-ray) has a single energy level. Irradiation of high-Z elements such as gold, silver or gadolinium with a synchrotron-generated monochromatic X-rays with the energy at or higher than their K-edge energy causes a photoelectric effect that includes release of the Auger electrons that induce DNA damage—leading to cell killing. Delivery of high-Z elements into cancer cells and tumor mass can be facilitated by the use of nanoparticles. Various types of nanoparticles containing high-Z elements have been developed. A recent addition to this growing list of nanoparticles is mesoporous silica-based nanoparticles (MSNs) containing gadolinium (Gd–MSN). The ability of Gd–MSN to inhibit tumor growth was demonstrated by evaluating effects of irradiating tumor spheroids with a precisely tuned monochromatic X-ray.

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“…Nanotechnology that was initiated in 1960s has generated a variety of nanomaterials valuable for biomedical applications such as cancer therapy [1]. Of particular interest are nanoparticles, small particles of the size ranging from 40 to 400 nm [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Convergence of the Study on Monochromatic X-rays and the Research on Nanoparticles Opens Up a Possibility to Develop a New Type of Radiation Therapy

Tamanoi¹,

Matsumoto²,

Đoàn³

et al. 2020

Preprint

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Conventional radiation therapy uses white X-rays that consist of a mixture of X-ray waves with various energy levels. In contrast, a monochromatic X-ray (monoenergetic X-ray) has a single energy level. Irradiation of high Z elements with a synchrotron generated monochromatic X-ray with the energy at or higher than the K-edge energy of the element results in the production of the Auger electrons that cause DNA damage leading to cell killing. Delivery of high Z elements into cancer cells and tumor mass can be facilitated by the use of nanoparticles. Mesoporous silica nanoparticles (MSNs) have been shown to be effective in delivering high Z elements to cancer cells. A proof of principle experiment was reported that demonstrated the feasibility of this approach. This opens up a possibility to pursue the Auger cancer therapy by the combined use of MSNs loaded with high Z elements and monochromatic X-rays. Similar cancer therapies using other types of quantum beams such as neutron, proton and carbon ion beams can be envisioned.

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Strategic use of nanotechnology in drug targeting and its consequences on human health: A focused review

Cited by 28 publications

References 187 publications

Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology

Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology

Studies on the Exposure of Gadolinium Containing Nanoparticles with Monochromatic X-rays Drive Advances in Radiation Therapy

Convergence of the Study on Monochromatic X-rays and the Research on Nanoparticles Opens Up a Possibility to Develop a New Type of Radiation Therapy

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