Strategic vaccination of hair sheep against Haemonchus contortus

Teixeira, Marcel; Matos, Antônio Francisco Igor Magalhães de; Albuquerque, Fernando Henrique Melo Andrade Rodrigues de; Bassetto, César Cristiano; Smith, William D.; Monteiro, J. P.

doi:10.1007/s00436-019-06367-x

Cited by 18 publications

(11 citation statements)

References 29 publications

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“…Appropriate pasture management should be a primary way to control haemonchosis, but this type of prevention is not sufficient in many cases. In spite of the advances in vaccination development [3], anthelmintic drugs are still the most important tool in the prophylaxis and treatment of H. contortus infection in grazing sheep [4]. The efficacy of anthelmintic therapy, however, decreases due to drug-resistance development in helminths, with the helminths' high fertility and short generational interval providing an enviable developmental plasticity in terms of adaptation and the fast development of drug resistance in H. contortus [1].…”

Section: Introductionmentioning

confidence: 99%

Sub-lethal doses of albendazole induce drug metabolizing enzymes and increase albendazole deactivation in Haemonchus contortus adults

Kellerová¹,

Stuchlíková²,

Matoušková³

et al. 2020

Vet Res

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The efficacy of anthelmintic therapy of farm animals rapidly decreases due to drug resistance development in helminths. In resistant isolates, the increased expression and activity of drug-metabolizing enzymes (DMEs), e.g. cytochromes P450 (CYPs), UDP-glycosyltransferases (UGTs) and P-glycoprotein transporters (P-gps), in comparison to sensitive isolates have been described. However, the mechanisms and circumstances of DMEs induction are not well known. Therefore, the present study was designed to find the changes in expression of CYPs, UGTs and P-gps in adult parasitic nematodes Haemonchus contortus exposed to sub-lethal doses of the benzimidazole anthelmintic drug albendazole (ABZ) and its active metabolite ABZ-sulfoxide (ABZSO). In addition, the effect of ABZ at sub-lethal doses on the ability to deactivate ABZ during consequent treatment was studied. The results showed that contact of H. contortus adults with sub-lethal doses of ABZ and ABZSO led to a significant induction of several DMEs, particularly cyp-2, cyp-3

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Section: Introductionmentioning

confidence: 99%

Sub-lethal doses of albendazole induce drug metabolizing enzymes and increase albendazole deactivation in Haemonchus contortus adults

Kellerová¹,

Stuchlíková²,

Matoušková³

et al. 2020

Vet Res

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“…The emergence of multi-drug resistance H. contortus has focussed research on development of alternative control strategies, such as selective breeding for animals resistant to infection [5] and vaccination [8]. A vaccine, Barbervax ® , comprising native proteins extracted from the nematode gut has been introduced in Australia [13] and tested with promising results in Brazil [14–16]. However, its widespread use is limited, mainly due to cost, licensing, requirement for multiple vaccinations and additional strategies, such as nutritional improvement [15].…”

Section: Introductionmentioning

confidence: 99%

Differences in immune responses to Haemonchus contortus infection in the susceptible Ile de France and the resistant Santa Ines sheep under different anthelmintic treatments regimens

Albuquerque¹,

Bassetto²,

Almeida³

et al. 2019

Vet Res

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Understanding the immunological basis of resistance to gastrointestinal nematode infections in livestock is important in order to develop novel methods of parasite control such as vaccination or genetic selection for parasite resistance. The present study aimed to investigate differences in immune response between parasite resistant Santa Ines and susceptible Ile de France sheep breeds to natural Haemonchus contortus infection. Parasitological parameters, humoral immunity, local and circulating cellular immune responses were evaluated in 19 Santa Ines and 19 Ile de France lambs undergoing different anthelmintic treatments regimens: suppressive treatments (SUP) or targeted selective treatments (TST) over a 5-month grazing period. Santa Ines lambs had significantly lower Haemonchus faecal egg count and worm burden compared to Ile de France regardless of treatment regime. In addition, circulating blood eosinophils count and parasite-specific IgG levels were significantly higher and more rapidly induced in Santa Ines lambs. Abomasal immune responses were generally greater in the resistant breed, which had significantly higher levels of parasite-specific IgA in mucus, and elevated number of globule leukocytes and CD3+ T cells within the abomasal mucosal. Furthermore, numbers of POU2F3+ epithelial cells, a tuft-cell specific transcription factor, were also elevated in the Santa Ines breed, suggesting that this breed is better able to initiate T-helper type 2 immune responses within the abomasum. In conclusion, the differential immunological responses detailed here are relevant to understanding resistance to gastrointestinal nematodes in other host breeds, as well as to resistance breeding as a sustainable control approach for parasitic infections.

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“…A sterile immunity does not result, infection is not completely prevented, but the worm burden is reduced and worm egg output is suppressed (Teixeira et al, 2019). Vaccinated lambs shed 80% fewer eggs than unvaccinated lambs in one study (Bassetto et al, 2018); ewe egg shedding was reduced by 87% and worm burden by 79%, with the peri-parturient rise also suppressed (Teixeira et al, 2019). This effect leads to lower levels of pasture contamination and so reduced challenge.…”

Section: Barbervaxmentioning

confidence: 99%

Haemonchosis: dealing with the increasing threat of the barber's pole worm

Crilly¹,

Evans

Tähepõld

et al. 2020

Livestock

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Haemonchus contortus is a trichostrongyle nematode parasite of sheep and goats, and worldwide is considered to be the most important parasite of these species. It has a similar lifecycle to other parasitic trichostrongyle gastrointestinal nematodes, but it has a markedly higher fecundity, a preference for higher temperatures and a short pasture development time, which makes it epidemiologically different. Similarly, because of its blood-feeding habit the disease produced is distinct from parasitic gastroenteritis. This article summarises the differences in biology and control of H. contortus to other gastrointestinal nematodes of sheep, and covers specific control measures such as the use of FAMACHA© scoring, use of closantel and nitroxynil, the H. contortus vaccine, the effect of copper oxide wire particles, and the potential for breeding haemonchosis-resistant sheep and other future developments in H. contortus control.

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Strategic vaccination of hair sheep against Haemonchus contortus

Cited by 18 publications

References 29 publications

Sub-lethal doses of albendazole induce drug metabolizing enzymes and increase albendazole deactivation in Haemonchus contortus adults

Sub-lethal doses of albendazole induce drug metabolizing enzymes and increase albendazole deactivation in Haemonchus contortus adults

Differences in immune responses to Haemonchus contortus infection in the susceptible Ile de France and the resistant Santa Ines sheep under different anthelmintic treatments regimens

Haemonchosis: dealing with the increasing threat of the barber's pole worm

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