Strategies and First Advances in the Development of Prevascularized Bone Implants

Rücker, Christoph; Kirch, Holger; Pullig, Oliver; Walles, Heike

doi:10.1007/s40610-016-0046-2

Cited by 8 publications

(4 citation statements)

References 101 publications

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“…Vascularization is a fundamental requirement for the viability of the bone tissue-engineered construct. Development of the predictably sufficient vascular network within the construct remains one of the main challenges of BTE [ 43 , 151 , 152 , 153 , 154 ]. A stable blood supply to the bone scaffold provides an influx of oxygen, nutrients, GF, and osteoprogenitor cells, that are essential for bone tissue regeneration and remodeling.…”

Section: Recent Developments In Bone Tissue Engineeringmentioning

confidence: 99%

In Vivo Bone Tissue Engineering Strategies: Advances and Prospects

et al. 2022

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Reconstruction of critical-sized bone defects remains a tremendous challenge for surgeons worldwide. Despite the variety of surgical techniques, current clinical strategies for bone defect repair demonstrate significant limitations and drawbacks, including donor-site morbidity, poor anatomical match, insufficient bone volume, bone graft resorption, and rejection. Bone tissue engineering (BTE) has emerged as a novel approach to guided bone tissue regeneration. BTE focuses on in vitro manipulations with seed cells, growth factors and bioactive scaffolds using bioreactors. The successful clinical translation of BTE requires overcoming a number of significant challenges. Currently, insufficient vascularization is the critical limitation for viability of the bone tissue-engineered construct. Furthermore, efficacy and safety of the scaffolds cell-seeding and exogenous growth factors administration are still controversial. The in vivo bioreactor principle (IVB) is an exceptionally promising concept for the in vivo bone tissue regeneration in a predictable patient-specific manner. This concept is based on the self-regenerative capacity of the human body, and combines flap prefabrication and axial vascularization strategies. Multiple experimental studies on in vivo BTE strategies presented in this review demonstrate the efficacy of this approach. Routine clinical application of the in vivo bioreactor principle is the future direction of BTE; however, it requires further investigation for to overcome some significant limitations.

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Section: Recent Developments In Bone Tissue Engineeringmentioning

confidence: 99%

In Vivo Bone Tissue Engineering Strategies: Advances and Prospects

et al. 2022

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“…The release of TA and GS from SP@(TA-GS/PF)*3 and SP@(TA-GS)*3 (4 mm (Φ) × 2 mm (h)) was evaluated by using a constant-temperature oscillator immersed in 500 μL of PBS at 37 °C, at a rate of 100 rpm. The 500 μL of PBS was added while the solution was being extracted at different periods (1,3,6,12,24,48,72,96,120,144, and 168 h) with the continuous oscillation. The content of TA and GS was detected by ultraviolet spectrophotometer at 216 nm and the fluorescence strategy based on OPA derivatization, respectively.…”

Section: Release Of Ta and Gs In Pbsmentioning

confidence: 99%

“…The requirement of medical implants for bone grafting has been widely presented in the orthopedic surgeries worldwide, which is ascribed to the increasing cases of bone defects that are caused by trauma, tumor, and other diseases. − Moreover, with the obesity and the aging of the population, the global adult diabetes rate will rise from 8.4% in 2017 to 9.9% in 2045 . Subsequently, more and more diabetic patients suffering from bone defects are found and need orthopedic surgeries .…”

Section: Introductionmentioning

confidence: 99%

Decorated Polyetheretherketone Implants with Antibacterial and Antioxidative Effects through Layer-by-Layer Nanoarchitectonics Facilitate Diabetic Bone Integration with Infection

Huang

Lin

Bai

et al. 2022

ACS Appl. Mater. Interfaces

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Patients suffering diabetic bone defects still need some new and effective strategies to achieve enhanced prognostic effects. Although medical implants are the common treatment of bone defects, the excessive oxidative stress and high risk of bacterial infection in diabetes mellitus lead to a higher risk of implant failure. To improve the healing ability of diabetic bone defects, herein, polyetheretherketone (PEEK) was modified through a developed layer-by-layer (LBL) construction strategy to obtain multifunctional PEEK (SP@(TA-GS/PF)*3) by the assembly of tannic acid (TA), gentamicin sulfate (GS) and Pluronic F127 (PF127) on the basis of prepared porous PEEK through sulfonation (SPEEK). The prepared SP@(TA-GS/PF)*3 exhibited sustained antimicrobial activity and enhanced the differentiation of osteoblast (MC3T3-E1) for needed osteogenesis. Moreover, SP@(TA-GS/PF)*3 scavenged excessive oxidative stress to promote the growth of H 2 O 2 damaged HUVEC with enhanced secretion of VEGF for neovascularization. In addition, the remarkable in vivo outcomes of angiogenesis and osseointegration were revealed by the subcutaneous implant model and bone tissue implant model in diabetic rats, respectively. The in vitro and in vivo results demonstrated that modified PEEK with multifunction can be an attractive tool for enhancing bone integration under diabetic conditions, underpinning the clinical application potential of modified implants for diabetic osseointegration.

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“…Bone xenografts provide an optimal microenvironment for cell adhesion, proliferation and infiltration in vitro and de novo bone generation in vivo. This osteoinductive effect is related to the preserved micro‐ and macro‐ structure of the decellularized bone together with the partial preservation of ECM components 188 . Despite their high availability, low cost and good mechanical and osteoinductive properties, only a few bone xenografts are available, which have shown limited positive clinical results, 189,190 and as a result, they are rarely employed in orthopaedics 191 .…”

Section: Xenografts In Clinical Indicationsmentioning

confidence: 99%

Decellularized xenografts in regenerative medicine: From processing to clinical application

Capella-Monsonís

Zeugolis

2021

Xenotransplantation

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Decellularized xenografts are an inherent component of regenerative medicine. Their preserved structure, mechanical integrity and biofunctional composition have well established them in reparative medicine for a diverse range of clinical indications. Nonetheless, their performance is highly influenced by their source (ie species, age, tissue) and processing (ie decellularization, crosslinking, sterilization and preservation), which govern their final characteristics and determine their success or failure for a specific clinical target. In this review, we provide an overview of the different sources and processing methods used in decellularized xenografts fabrication and discuss their effect on the clinical performance of commercially available decellularized xenografts.

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Strategies and First Advances in the Development of Prevascularized Bone Implants

Cited by 8 publications

References 101 publications

In Vivo Bone Tissue Engineering Strategies: Advances and Prospects

In Vivo Bone Tissue Engineering Strategies: Advances and Prospects

Decorated Polyetheretherketone Implants with Antibacterial and Antioxidative Effects through Layer-by-Layer Nanoarchitectonics Facilitate Diabetic Bone Integration with Infection

Decellularized xenografts in regenerative medicine: From processing to clinical application

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