Strategies and progresses for enhancing targeted antibiotic delivery

Nazli, Adila; He, David; Liao, Dongmei; Khan, Muhammad Zafar; Huang, Chao; He, Yun

doi:10.1016/j.addr.2022.114502

Cited by 43 publications

(17 citation statements)

References 334 publications

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“…Therefore, local release of antibiotics has become a focus of attention for researchers. Topical antibiotic therapy is the delivery of drugs to the site of infection, and it reduces the minimum dose of drug required 181 . Local release of antibiotics increases the therapeutic concentration of the drug, thereby reducing systemic absorption of the drug and reducing the potential risk of adverse effects and bacterial resistance.…”

Section: Electrospinning Wound Dressing With Functional Substancementioning

confidence: 99%

“…Topical antibiotic therapy is the delivery of drugs to the site of infection, and it reduces the minimum dose of drug required. 181 Local release of antibiotics increases the therapeutic concentration of the drug, thereby reducing systemic absorption of the drug and reducing the potential risk of adverse effects and bacterial resistance. Amiri et al 59 utilized nanofibers composed of CS and PEO combined with teicoplanin for localized antibiotic delivery and wound healing purposes.…”

Section: Antibacterial Agentmentioning

confidence: 99%

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Advances in wound dressing based on electrospinning nanofibers

Zhang,

Wang,

Gao

et al. 2023

J of Applied Polymer Sci

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In recent years, there has been a significant focus on bioactive dressings suitable for treating chronic and acute wounds. Electrospinning nanofibers are considered advanced dressing options due to their high porosity and permeability to air and water, effective barrier properties against external pathogens, and excellent resemblance to the extracellular matrix for wound healing and skin regeneration. This article reviews the recent advancements in the application of electrospinning nanofibers for bioactive wound healing. The review begins with an overview of the wound healing process and electrospinning methods. It then explores the advantages and disadvantages of different synthetic and natural polymers used in the preparation of electrospinning wound dressings. The natural polymers discussed in this review include collagen, gelatin, silk fibroin, chitosan, hyaluronic acid, and sodium alginate. Additionally, the review delves into commonly used synthetic polymers like polyvinyl alcohol, polyvinyl chloride, polyethylene lactone, polylactide, and polyurethane for wound dressing applications. Furthermore, the review examines the blending of natural and synthetic polymers to create high‐performance wound dressings. It also explores the incorporation of functional additives, such as antimicrobial agents, growth factors, and natural extracts, into electrospinning nanofibers to expedite wound healing and tissue repair. In conclusion, electrospinning is an emerging technology that provides unique opportunities for designing more effective wound dressings and care products.

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Section: Electrospinning Wound Dressing With Functional Substancementioning

confidence: 99%

Section: Antibacterial Agentmentioning

confidence: 99%

Advances in wound dressing based on electrospinning nanofibers

Zhang,

Wang,

Gao

et al. 2023

J of Applied Polymer Sci

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“…Nanocarriers can selectively transport antibiotics to the site of infection due to their targeting properties, thus improving drug distribution, increasing the effectiveness of antibiotics, reducing drug side effects and overcoming bacterial resistance ( Nazli et al, 2022 ). Many nanomaterials have been used in antimicrobial therapy, such as inorganic metal nanomaterials (gold, silver, copper, zinc, titanium), metal oxide nanoparticles (copper oxide, zinc oxide, titanium oxide, iron oxide), carbon-based nanomaterials (graphene and its derivatives, graphene quantum dots, carbon quantum dots), and organic nanostructures (chitosan, dendrimers, liposomes, micelles, vesicles), etc.…”

Section: Introductionmentioning

confidence: 99%

“…( Modi et al, 2022 ). The antibacterial mechanisms of nanomaterials involve 1) the use of size, surface properties and other unique physicochemical properties to damage important intracellular components and interfere with the normal physiological metabolic processes of bacteria, ultimately leading to bacterial death ( Cheng et al, 2022 ); 2) the use of the enzyme-like activity of nanomaterials, regulating the level of reactive oxygen species (ROS) to exert a strong bactericidal effect by disrupting bacterial biofilms ( Godoy-Gallardo et al, 2021 ); 3) smart response platforms based on nanomaterials, such as pH, enzymes and temperature to enhance antimicrobial activity ( Jiang et al, 2020 ); 4) the use of external stimulus-response properties of nanomaterials, such as light and microwaves, or synergistic antimicrobial drugs to achieve an antimicrobial activity in a single or combined treatment ( Díez-Pascual, 2020 ; Nazli et al, 2022 ). Zeolite imidazole ester skeleton—8 (ZIF—8) is a porous crystalline material formed by the coordination self-assembly of zinc ion and 2-methylimidazole.…”

Section: Introductionmentioning

confidence: 99%

A fresh pH-responsive imipenem-loaded nanocarrier against Acinetobacter baumannii with a synergetic effect

Gui

Feng

et al. 2023

Front. Bioeng. Biotechnol.

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In recent years, the treatment of Acinetobacter baumannii infections has become a pressing clinical challenge due to its increasing incidence and its serious pathogenic risk. The research and development of new antibacterial agents for A. baumannii have attracted the attention of the scientific community. Therefore, we have constructed a new pH-responsive antibacterial nano-delivery system (Imi@ZIF-8) for the antibacterial treatment of A. baumannii. Due to its pH-sensitive characteristics, the nano-delivery system offers an improved release of the loaded imipenem antibiotic at the acidic infection site. Based on the high loading capacity and positive charge of the modified ZIF-8 nanoparticles, they are excellent carriers and are suitable for imipenem loading. The Imi@ZIF-8 nanosystem features synergistic antibacterial effects, combining ZIF-8 and imipenem to eliminate A. baumannii through different antibacterial mechanisms. When the loaded imipenem concentration reaches 20 µg/mL, Imi@ZIF-8 is highly effective against A. baumannii in vitro. Imi@ZIF-8 not only inhibits the biofilm formation of A. baumannii but also has a potent killing effect. Furthermore, in mice with celiac disease, the Imi@ZIF-8 nanosystem demonstrates excellent therapeutic efficacy against A. baumannii at imipenem concentrations of 10 mg/kg, and it can inhibit inflammatory reaction and local leukocyte infiltration. Due to its biocompatibility and biosafety, this nano-delivery system is a promising therapeutic strategy in the clinical treatment of A. baumannii infections, providing a new direction for the treatment of antibacterial infections.

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“…[7] A promising strategy is using intracellular delivery to enhance the antibacterial efficacy of currently available antibiotics. [8] For example, conjugation of anti-S. aureus antibody to rifalogue significantly boosted the antibacterial capability of the antibiotic to kill intracellular S. aureus. [9] However, antibody variability may weaken the antibacterial efficacy of these antibody-antibiotic conjugates and thus limit their further applications.…”

Section: Introductionmentioning

confidence: 99%

Tandem Guest‐Host‐Receptor Recognitions Precisely Guide Ciprofloxacin to Eliminate Intracellular Staphylococcus aureus

Zhan

Liu

et al. 2023

Angewandte Chemie

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Staphylococcus aureus (S. aureus) is able to hide within host cells to escape immune clearance and antibiotic action, causing life-threatening infections. To boost the therapeutic efficacy of antibiotics, new intracellular delivery approaches are urgently needed. Herein, by rational design of an adamantane (Ada)-containing antibiotic-peptide precursor Ada-Gly-Tyr-Val-Ala-Asp-Cys(StBu)-Lys(Ciprofloxacin)-CBT (Cip-CBT-Ada), we propose a strategy of tandem guest-hostreceptor recognitions to precisely guide ciprofloxacin to eliminate intracellular S. aureus. Via guest-host recognition, Cip-CBT-Ada is decorated with a β-cyclodextrinheptamannoside (CD-M) derivative to yield Cip-CBT-Ada/CD-M, which is able to target mannose receptoroverexpressing macrophages via multivalent ligandreceptor recognition. After uptake, Cip-CBT-Ada/ CD-M undergoes caspase-1 (an overexpressed enzyme during S. aureus infection)-initiated CBT-Cys click reaction to self-assemble into ciprofloxacin nanoparticle Nano-Cip. In vitro and in vivo experiments demonstrate that, compared with ciprofloxacin or Cip-CBT-Ada, Cip-CBT-Ada/CD-M shows superior intracellular bacteria elimination and inflammation alleviation efficiency in S. aureus-infected RAW264.7 cells and mouse infection models, respectively. This work provides a supramolecular platform of tandem guest-host-receptor recognitions to precisely guide antibiotics to eliminate intracellular S. aureus infection efficiently.

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Strategies and progresses for enhancing targeted antibiotic delivery

Cited by 43 publications

References 334 publications

Advances in wound dressing based on electrospinning nanofibers

Advances in wound dressing based on electrospinning nanofibers

A fresh pH-responsive imipenem-loaded nanocarrier against Acinetobacter baumannii with a synergetic effect

Tandem Guest‐Host‐Receptor Recognitions Precisely Guide Ciprofloxacin to Eliminate Intracellular Staphylococcus aureus

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