Straw is a general term for the stem and leaf parts of mature crops, and is a multi-purpose renewable biomass energy resource in the agricultural ecosystem. The prospect of comprehensive utilization of straw has become broad with the development of agricultural production, the advancement of science and technology, and the improvement of the level of agricultural mechanization. The comprehensive utilization of straw plays an important role in enhancing the sustainable development ability of agricultural economy and improving the current situation of comprehensive utilization of agricultural resources in my country. This paper briefly combs the development history of straw and the prospect and current situation of comprehensive utilization, and expounds the separation technology of straw components, straw man-made panels, straw concrete, straw returning technology and oyster mushroom cultivation. It focuses on the description of the component separation technology of straw and the manufacturing process of straw-based panels. The different separation methods and separation effects of cellulose, hemicellulose and lignin were introduced in detail, and the static yield strength (MOR), internal bonding strength (IB) and water absorption thickness of several common straw-based panels were compared and studied (TS). Finally, it summarizes the benefit analysis of the comprehensive utilization of straw by scholars from the perspective of economics, and summarizes the corresponding measures based on their own views.