2016
DOI: 10.1021/acs.chemrev.6b00476
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Strategies for Corrole Functionalization

Abstract: This review covers the functionalization reactions of meso-arylcorroles, both at the inner core, as well as the peripheral positions of the macrocycle. Experimental details for the synthesis of all known metallocorrole types and for the N-alkylation reactions are presented. Key peripheral functionalization reactions such as halogenation, formylation, carboxylation, nitration, sulfonation, and others are discussed in detail, particularly the nucleophilic aromatic substitution and the participation of corroles i… Show more

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Cited by 201 publications
(119 citation statements)
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“…Corroles are also a group of tetrapyrrolic derivatives strongly related with porphyrins which are also playing a special role in PDT medicinal applications (Barata et al 2017). In such way, the strategy of conjugation of a CD to a corrole derivative in order to increase the PS solubility, contributing to an efficient delivery of the drug to the tumoral cell, was also reported by the same research group.…”
Section: Cancer Pdt and Porphyrin-type Derivatives 1003mentioning
confidence: 99%
“…Corroles are also a group of tetrapyrrolic derivatives strongly related with porphyrins which are also playing a special role in PDT medicinal applications (Barata et al 2017). In such way, the strategy of conjugation of a CD to a corrole derivative in order to increase the PS solubility, contributing to an efficient delivery of the drug to the tumoral cell, was also reported by the same research group.…”
Section: Cancer Pdt and Porphyrin-type Derivatives 1003mentioning
confidence: 99%
“…Recent developments on chemical functionalization approaches of corroles have given new impetus to the application of these compounds in several areas [1][2][3][4][5][6]. For example, they are used in the therapeutic field as inactivation agents for bacteria, viruses, and fungi; contrast agents for biomedical imaging; photosensitizers for photodynamic therapy to fight cancer [7][8][9][10][11][12][13][14][15][16]; and also as catalysts [5] and sensors [4].…”
Section: Introductionmentioning
confidence: 99%
“…[2] This coincided with the isolation of 5,10,15-tris-(pentafluorophenyl)corrole,the first free-base corrole that is truly stable (owing to its electron-withdrawing meso-C 6 F 5 groups). [3] Still, in contrast with the non-substituted porphyrin (porphine), [4] thec orresponding "naked" corrole and sapphyrin (the expanded pentapyrrolic macrocycle) were not yet reported;a nd the access to derivatives with no b-pyrrole substituents and only alkyl substituents on their corresponding meso-C atoms remains very limited. [3] Still, in contrast with the non-substituted porphyrin (porphine), [4] thec orresponding "naked" corrole and sapphyrin (the expanded pentapyrrolic macrocycle) were not yet reported;a nd the access to derivatives with no b-pyrrole substituents and only alkyl substituents on their corresponding meso-C atoms remains very limited.…”
mentioning
confidence: 99%
“…[2b] Large efforts on developing modified and new synthetic methods led to the current stage:c orroles with almost any meso-aryl substituents are nowadays accessible in quite straightforward fashions. [3,5] Hemes present in numerous enzymes do not have any meso-C-substituents and the cobalt complexes of porphine, and 5,10,15,20-tetramethylporphyrin are among the most efficient electrocatalysts. [3,5] Hemes present in numerous enzymes do not have any meso-C-substituents and the cobalt complexes of porphine, and 5,10,15,20-tetramethylporphyrin are among the most efficient electrocatalysts.…”
mentioning
confidence: 99%
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