Strategies for coupling solid-phase microextraction with mass spectrometry

Deng, Jiewei; Yang, Yunyun; Wang, Xiaowei; Luan, Tiangang

doi:10.1016/j.trac.2013.12.004

Cited by 101 publications

(83 citation statements)

References 82 publications

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“…Solid phase microextraction is a sample preparation and sampling technique developed by Pawlizny in 1990 [11,12] which has been employed on a wide range of analytes and for several applications in various research fields, such as environmental chemistry, forensic chemistry and pharmaceutical and food industries [13][14][15][16][17]. It allows a fast and solvent-free sampling and it is mainly applied coupled with GC-MS or other chromatographic techniques [18].…”

Section: Introductionmentioning

confidence: 99%

At-line characterisation of compounds evolved during biomass pyrolysis by solid-phase microextraction SPME-GC-MS

Conti

Fabbri

Torri

et al. 2016

Microchemical Journal

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At-line sampling by solid phase microextraction (SPME) followed by GC-MS analysis was investigated as a fast analytical method to identify and quantify the compounds evolved during intermediate pyrolysis of biomass. A 75 μm carboxen/polidimethylsiloxane (CAR/PDMS) coated fiber in retracted configuration was inserted at-line during pyrolysis at 500 °C with a bench scale fixed bed pyrolyzer of different biomass substrates, lignocellulosic feedstock, agricultural wastes, animal residues and algal biomass. The molecular composition resulting from SPME sampling was compared to the chemical composition of collected pyrolysis liquid, which included the aqueous and organic phase (bio-oil). The storage capacity of the SPME fiber was tested 48 and 96 h after sampling under air atmosphere and vacuum-packed plastic bags. The SPME-GC-MS profiles could be utilized to gather information on the characteristics of pyrolysis process, such as the efficiency of vapor condensation

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Section: Introductionmentioning

confidence: 99%

At-line characterisation of compounds evolved during biomass pyrolysis by solid-phase microextraction SPME-GC-MS

Conti

Fabbri

Torri

et al. 2016

Microchemical Journal

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“…Thanks to the flexibility and effective clean up afforded by SPME devices, it is possible to couple SPME directly with MS. In a recent review by Deng at al., different strategies of SPME-MS coupling were discussed in detail [89]. Interestingly, SPME was demonstrated to be a suitable method for analysis of drugs from small sample volumes, similarly to Dried Matrix Spot (blood, urine) [84,90].…”

Section: Therapeutic Drug Monitoring Point-of-care and On-site Analysismentioning

confidence: 99%

SPME as a promising tool in translational medicine and drug discovery: From bench to bedside

Goryński

Goryńska

Górska

et al. 2016

Journal of Pharmaceutical and Biomedical Analysis

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“…Coupling SPME to ambient mass spectrometry (AMS) is an effective strategy to improve the sensitivity and suppress the matrix effects for direct analysis of complex samples [183][184][185]. Thus, coupling SPME, the derivatization with AMS gives promising prospects in environmental applications.…”

Section: Summary and Future Trendsmentioning

confidence: 99%

Application of Solid-Phase Microextraction Combined with Derivatization for Polar Compound Sampling in Environmental Analysis

Yang¹,

Luan²

2016

Solid Phase Microextraction

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Solid-phase microextraction (SPME) is a solvent-free sample preparation technique using a fused-silica fiber coated with an appropriate stationary phase. Derivatization is often necessary to determine substances with poor chromatographic behavior, high reactivity, and/or volatility or thermal instability. SPME derivatization technique can be operated under different combined modes and may be influenced by factors such as sample matrix, SPME, derivatization, and desorption condition. Combined with derivatization, HS-SPME, DI-SPME, membrane-protected SPME, and in-tube SPME have been applied to the analysis of a vast amount of chemicals, i.e., aldehydes and acetone, amines, organic acids, phenolic compounds, pesticide, metal and organic metal species, and pharmaceutical and personal care products (PPCPs) in a wide range of environmental matrices, including air, water, soil, and sediment samples. This chapter reviews the mode and method development of the derivatization technique, the derivatization reagents, and reaction mechanism, as well as its applications in environmental analysis.

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Strategies for coupling solid-phase microextraction with mass spectrometry

Cited by 101 publications

References 82 publications

At-line characterisation of compounds evolved during biomass pyrolysis by solid-phase microextraction SPME-GC-MS

At-line characterisation of compounds evolved during biomass pyrolysis by solid-phase microextraction SPME-GC-MS

SPME as a promising tool in translational medicine and drug discovery: From bench to bedside

Application of Solid-Phase Microextraction Combined with Derivatization for Polar Compound Sampling in Environmental Analysis

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